高精度散射光度滴定法测定苯妥英钠  

Determination of Phenytoin Sodium by Highly-Accurate Nephelometric Titrimetry

作　　者：易涛[1] 李成容[1] 何宁[1] 詹先成[1] 林涛[1] 

机构地区：[1]四川大学华西药学院,成都610041

出　　处：《分析化学》2004年第1期76-78,共3页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金资助项目 (No .3 9770 882 )

摘　　要：用高精度散射光度滴定法测定苯妥英钠的含量。以 2 %糊精溶液作为胶体保护剂 ,用硝酸银标准溶液滴定苯妥英钠 ,生成沉淀的溶度积常数小 (Ksp=3× 10 -10 ) ,滴定曲线尖锐 ,可以准确判断滴定终点。高精度散射光度滴定法、重量法和电位滴定法测得苯妥英钠的含量分别为 98.82 %、98.72 %和 98.75 %。F检验和t检验结果显示高精度散射光度滴定法测定苯妥英钠 ,在精密度和准确度方面与重量法、电位滴定法测定结果均无显著差异 (α >0 .0 5 )。The phenytoin sodium was determined by highly-accurate nephelometric titrimetry. In the titration, silver nitrate solution was used as the titrant and 2 % dextrin solution serves as a colloid stabilizer. The solubility product constant of the precipitation was determined to be 3×10 -10. The peak of the titration curve is sharp enough to indicate the titration end-point. The contents of the phenytoin sodium determined by highly-accurate nephelometric titrimetry, gravimetry and potentiometric titrimetry was 98.82%, 98.72%, and 98 75% respectively. The results of F test and t test demonstrate that the precision and the accuracy of highly-accurate nephelometric titrimetry are comparable to those of gravimetry and potentiometric titrimetry (α>0 05).

关 键 词：高精度散射光度滴定法 测定 苯妥英钠 溶度积常数 药物分析 

分 类 号：O657.3[理学—分析化学]