奥氮平与利培酮治疗伴激越症状的精神分裂症或分裂样精神障碍效果比较  

Olanzapine and risperidone in the treatment with agitated symptoms of schizophrenia or schizophreniform disorder

作　　者：庞润慧 李捷[1] 刘晓[1] 

机构地区：[1]天水市第三人民医院五病区,甘肃天水741000

出　　处：《现代医学与健康研究电子杂志》2017年第4期16-18,共3页Modern Medicine and Health Research

摘　　要：目的比较奥氮平与利培酮治疗伴激越症状的精神分裂症或分裂样精神障碍的临床疗效。方法抽选2013年12月至2014年12月于我院住院接受治疗的92例伴激越症状的精神分裂症或分裂样精神障碍患者作为研究对象,将其依据不同的治疗方法随机分为奥氮平组与利培酮组,于治疗结束后借助于PANSS(阳性及阴性症状量表)、PEC(兴奋分量表)对两组患者治疗疗效进行观察、比较。结果两组患者随着治疗时间的增进,精神分裂症均得到较好疗效,且除了治疗6周以外,两组PANSS评分在治疗第1、第2、第4周末均有显著差异存在(P<0.05),另外除治疗第1周外,奥氮平组PEC评分在其他各治疗时间均显著低于利培酮组,存在统计学意义(P<0.05);虽然奥氮平组患者治疗总有效率优于利培酮组,但组间数据差异并无统计学意义(P>0.05)。结论奥氮平与利培酮对精神分裂症患者的阳性及阴性症状均有较好的治疗效果,且疗效相近,但就治疗患者伴激越症方面,奥氮平使用疗效优于利培酮。对于伴激越症状的精神分裂症或分裂样精神障碍患者来说,奥氮平可作为临床一线药物使用。Objective To compare olanzapine and risperidone in the treatment with agitation of the spirit of the schizophrenia or schizophreniform disorder. Methods Selected 92 cases of patients with the spirit of the schizophrenia or schizophreniform disorder in our hospital from Dec 2013 to Dec 2014,they were divided into olanzapine group and risperidone group,and then compared the curative effect of two groups. Results The schizophrenia was better after cure in two groups. The PANSS scores of week1,week2 and week4 had statistical difference(P<0.05). The PEC scores of olanzapine group was lower than risperidone group besides the week1,there had the statistical difference(P<0.05). There had no statistical difference between two groups though the total curative effect of olanzapine group was better than risperidone group(P>0.05). Conclusion Olanzapine and risperidone on mental Division) in patients with positive and negative symptoms has good treatment effect,and the effect is similar,but in the treatment of patients with acute agitation disorder aspects,olanzapine has more effective than risperidone. For patients with agitated symptoms of schizophrenia or schizophreniform disorder,olanzapine can be used as a first-line drugs.

关 键 词：奥氮平 利培酮 精神分裂症 分裂样精神障碍 

分 类 号：R749.3[医药卫生—神经病学与精神病学]