肾上腺素在新生儿心肺复苏时合理应用的临床研究  

The Best Appropriate Application of Epinephrine in Neonatal Cardiopulmonary Resuscitation

作　　者：沈红红[1] 吴红勇[1] 钟少珊[1] 陈惠珍[1] 

机构地区：[1]深圳市西乡人民医院儿科,518102

出　　处：《岭南急诊医学杂志》2003年第2期92-94,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨新生儿心肺复苏时肾上腺素的最佳用药浓度、剂量及给药途径。方法:102例新生儿心肺复苏病例,按肾上腺素的不同用药浓度、剂量与用药方法随机分为Ⅰ、Ⅱ、Ⅲ、Ⅳ四组。Ⅰ组用1:1000浓度肾上腺素0.01—0.03 mg/kg,静脉给药;Ⅱ组用1:1000浓度肾上腺素0.01—0.03 mg/kg,气管内给药;Ⅲ组用1:1000浓度肾上腺素0.1～0.2mg/kg,静脉给药;Ⅳ组用1:1000浓度肾上腺素0.01 mg&g,静脉给药。结果:Ⅰ、Ⅱ、Ⅲ组肾上腺素首剂有效率均明显高于Ⅳ组(P<0.05),而在Ⅰ、Ⅱ、Ⅲ三组间无统计学差异(P>0.05);短期存活Ⅰ、Ⅱ、Ⅲ三组也明显高于Ⅳ组(P<0.05);长期存活中Ⅰ、Ⅱ组明显高于Ⅲ、Ⅳ组(P<0.05),Ⅲ、Ⅳ组无统计学意义(P>0.05)。结论:新生儿复苏时最合适的肾上腺素浓度为1:1000,剂量为0.01～0.03 mg/kg。气管内给药与静脉给药均可,气管内给药远期疗效稍佳。Objective:To discuss how to use the epinephrine for improving the successful rate of neonatal cardiopulmonary resuscitation (CPR). Methods: 102 cases newborn who suffers sudden stop of breath and heartbeat have been treated by the epinephrine that includes different concentration,dose,and approach. All cases are divided four groups. Group Ⅰ uses 1-1000 concentration 0.01-0.03 mg/kg dose epinephrine by vein injection; Group Ⅱ uses 1:1000 concentration 0.01-0.03 mg/kg dose epinephrine by inside trachea; Group Ⅲ uses 1:1000 concentration 0.1-0.2 mg/kg dose epinephrine by vein injection; Group Ⅳ uses 1:1000 concentrations 0.01 mg/kg dose epinephrine by vein injection. Results:Group Ⅰ and Group Ⅱ have received good results in the short and long term livability separately, comparison Group Ⅲ and Group Ⅳ. Conclusions:The best appropriate epinephrine concentration 1:1000 and 0.01-0.03 mg/kg dose in neonatal CPR, which can increase marketly the neonatal successful rate of CPR. Inside trachea and vein may be good, but long term livability is better in inside trachea.

关 键 词：肾上腺素 新生儿 心肺复苏 临床资料 剂量 给药途径 

分 类 号：R459.6[医药卫生—治疗学]