KAIl基因与恶性肿瘤浸润相关性的研究  

Study on correlations of KAIl gene and its TM4SF family-related members with infiltration of malignant tumors

作　　者：夏志军[1] 张淑兰[1] 

机构地区：[1]中国医科大学二院妇产科,辽宁沈阳110004

出　　处：《国外医学（妇幼保健分册）》2003年第6期439-443,共5页Foreign Medical Sciences (Section of Maternal and Child Health)

基　　金：辽宁省科技基金项目 (981 0 50 0 1 0 4 )

摘　　要：浸润和转移是恶性肿瘤的重要特征 ,也是引起肿瘤病例死亡的主要原因。KAIl CD82属四次跨膜超家族的成员 ,其结构为细胞膜糖蛋白。目前研究多种肿瘤中均证实了转移的肿瘤往往伴随KAIl CD82基因的表达下降或缺失 ,最新研究发现TM 4SF家族部分成员可与整合素形成复合体 ,从而调节整合素的黏附功能 ,并影响整合素介导的细胞转移。Invasion and metastasis are two important characteristics of malignant tumor, and they are main death causes of the patients with cancer. KAIl/CD82 is a member of transmembrane 4 superfamily(TM4SF), and its structure is a glycoprotein on the cellular membrane. From recent studies on different kinds of neoplasms, it is confirmed that the metastasized tumor is often accompanied by decrease or absence in expression of KAIl/CD82 gene. Recent study showed that parts of TM4SF and integrin can form a complex, which can regulate adhesive function of integrin and influence integrin mediated cell metastasis.

关 键 词：KAIL/CD82 TM4SF 恶性肿瘤 转移 

分 类 号：R737.39[医药卫生—肿瘤]