LHRH类似物在卵巢癌治疗中的应用  

Application of LHRH analogues in treatment of ovarian cancer

作　　者：管睿[1] 崔英[1] 

机构地区：[1]第二军医大学第一附属长海医院妇产科,上海200433

出　　处：《国外医学（妇幼保健分册）》2003年第6期413-416,共4页Foreign Medical Sciences (Section of Maternal and Child Health)

摘　　要：卵巢癌是激素依赖性肿瘤 ,LHRHa除了通过下丘脑 垂体 性腺轴间接抑制卵巢癌细胞外 ,还通过癌细胞上LHRH受体介导 ,直接抑制癌细胞增殖、诱导凋亡。此外 ,还可以运用LHRHa对细胞的靶效应 ,将LHRHa作为载体载上细胞毒性物 ,从而可以提高细胞毒性药物的功效、降低毒副作用。Ovarian cancer is a kind of hormone dependent cancer. LHRH analogues not only present antitumor effects on ovarian cancer by suppressing the hypothalamus pituitary gonadal axis, but also directly inhibit the proliferation and induce the apoptosis through LHRH receptors activated by ovarian carcinoma cell. In addition, LHRH analogues targeting to LHRH receptors on the tumor cell can carry cytotoxic agents, and then these targeting cytotoxic LHRH analogues result in more curative effect and less toxic effect. In a word, treatment with LHRH analogues may be a valuable alternative for obstinate ovarian cancer.

关 键 词：LHRH类似物 卵巢癌 

分 类 号：R737.31[医药卫生—肿瘤]