Fluorescence microscopic morphology and inhibition ratestudies on apoptosis of osteosarcoma cells induced by ^(153)Sm  

作　　者：ZHU Shou-Peng, XIAO Dong, HAN Xiao-Feng (Suzhou Medical College, Sizhou 215007) 

出　　处：《Nuclear Science and Techniques》2000年第4期263-266,共4页核技术（英文）

基　　金：Supported by the International Atomic Energy Agency

摘　　要：The apoptosis of osteosarcoma cells treated with irradiation by 153Sm-EDTMP was studied. The morphological changes in osteosarcoma cells were observed by fluorescence microscopy. It was found that osteosarcoma cells exposed with 153Sm-EDTMP displayed significant nuclear fragmentation and marked pyknosis. With the prolongation of observing period, the membrane bound apoptotic bodies formation was observed. It should be noted, that with the lengthening of irradiation time by 153Sm-EDTMP, the inhibition rate of proliferation of osteosarcoma cells increased progressively.The apoptosis of osteosarcoma cells treated with irradiation by 153Sm-EDTMP was studied. The morphological changes in osteosarcoma cells were observed by fluorescence microscopy. It was found that osteosarcoma cells exposed with 153Sm-EDTMP displayed significant nuclear fragmentation and marked pyknosis. With the prolongation of observing period, the membrane bound apoptotic bodies formation was observed. It should be noted, that with the lengthening of irradiation time by 153Sm-EDTMP, the inhibition rate of proliferation of osteosarcoma cells increased progressively.

关 键 词：钐153 ^153SM-EDTMP 放射性核素标记 荧光显微镜 胃肉瘤 肿瘤细胞 细胞凋亡 

分 类 号：R738.1[医药卫生—肿瘤] R730.55[医药卫生—临床医学]