Progress and perspective of the kinetochore-associated motor proteins  

作　　者：LIU Dan, JIN Changjiang & YAO Xuebiao Institute of Cell Dynamics, University of Science and Technology of China, Hefei 230027, China Correspondence should be addressed to Yao Xuebiao (e-mail: [e-mail]) 

出　　处：《Chinese Science Bulletin》2003年第2期111-117,共7页

摘　　要：The kinetochore is structurally composed offour layers. We know that three microtubule-based motorproteins such as CENP-E, dynein, and MCAK are located at the outmost region of the kinetochore. Experimentation ofthese motor functions betters our understanding of mitotic regulation, and chromosome movements in particular.With real-time studies of chromosome movements in livecells, we hope to illustrate the molecular mechanisms under-lying mitotic regulation.The kinetochore is structurally composed offour layers. We know that three microtubule-based motorproteins such as CENP-E, dynein, and MCAK are located at the outmost region of the kinetochore. Experimentation ofthese motor functions betters our understanding of mitotic regulation, and chromosome movements in particular.With real-time studies of chromosome movements in livecells, we hope to illustrate the molecular mechanisms under-lying mitotic regulation.

关 键 词：着丝点 CENP-E MCAK 有丝分裂 调节 分子机制 运动蛋白 动力蛋白 

分 类 号：Q51[生物学—生物化学]