Effect of antiemetic drugs on decrease in gastric emptying in experimental model of motion sickness in rats  

止吐药物对大鼠实验性晕动病模型产生的胃排空抑制的影响(英文)

作　　者：YK GUPTA Geeta CHAUDHARY 

机构地区：[1]Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India,Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India

出　　处：《Acta Pharmacologica Sinica》2003年第4期296-300,共5页中国药理学报（英文版）

摘　　要：AIM: To study the effect of pretreatment with different antiemetic drugs on the motion sickness-induced inhibition in gastric emptying. METHODS: The rats were rotated for a period of 45 min at the rate of 30 rotations per min. RESULTS: Rotating the rats caused a significant decrease in gastric emptying as compared to the non-rotated group. Pretreatment with scopolamine (5 mg/kg, ip) did not reverse the delay in gastric emptying, while it per se caused inhibition of gastric emptying in the non-rotated group. Similarly other drugs mepyramine, cisapride, and granisetron did not have any effect on delay in gastric emptying caused by rotation. However beta blocker propranolol could partially but significantly reverse the decrease in gastric emptying. CONCLUSION: The present study demonstrated the potential use of propranolol as adjuvant with conventional antiemetics for motion sickness to combat associated secondary symptoms.AIM：To study the effect of pretreatment with different antiemetic drugs on the motion sickness-induced inhibition in gastric emptying.METHODS:The rats were rotated for a period of 45 min at the rate of 30 rotations per min.RESULTS:Rotating the rats caused a significant decrease in gastric emptying as cvompared to the non-rotated group.Pretreatment with scopolamine(5 mg/kg,ip)did not reverse the delay in gastric emptying,while it per se caused inhibition of gastric emptying in the non-rotated group.Similarly other drugs mepyramine,cisapride,and granisetron did not have any effect on delay in gastric emptying caused by rotation.However beta blocker propranolol could partially but significantly reverse the decrease in gastric emptying.CONCLUSION:The present study demonstrated the potential use of propranolol as adjuvant with conventional antiemetics for motion sickness to combat associated secondary symptoms.

关 键 词：gastric emptying motion sickness CISAPRIDE SCOPOLAMINE PROPRANOLOL mepyramine RATS 

分 类 号：R96[医药卫生—药理学]