氧自由基损伤在老年轻度认知功能损害发病机制中的作用  

The effect of free radical injury in the mechanism of senile mild cognitive impairment

作　　者：于宝成[1] 欧阳丽莎[1] 王玉敏[1] 王成章[1] 谭清武[1] 

机构地区：[1]解放军白求恩国际和平医院干部病房二科,河北石家庄050082

出　　处：《解放军保健医学杂志》2003年第4期227-229,共3页Journal Of Health Care And Medicine in Chinese Pla

摘　　要：目的 了解轻度认知功能损害(MCI)患者血清维生素E(Vit E)、超氧化物歧化酶(SOD)和丙二醛(MDA)的水平,探讨氧自由基损伤在老年轻度认知损害发病机制中的作用。方法 采用1:1配对病例对照设计,应用紫外分光光度法测定了45例老年MCI患者和45例健康老年人血清Vit E、SOD和MDA的含量,并进行分析。结果 老年MCI患者血清Vit E含量及SOD活性显著低于健康老年人(P<0.01),血清MDA含量显著高于健康老年人(P<0.01)。结论 氧自由基损伤参与了MCI的病理生理过程;临床上应给予外源性Vit E以进行早期干预治疗。Objective To explore the clinical significance of serum vitamin E (Vit E), superoxide dismutase (SOD) and malondialde-hyde (MDA) in patients with mild cognitive impairment (MCI). Methods A paired design of 45 MCI and 45 healthy elderly ones was adopt-ed. The contents of serum vitamine E (Vit E), superoxide dismufase (SOD) and malondialdehyde (MDA) were assayed. Results The level ofserum Vit E and the activity of SOD in MCI were significantly lower than that of elder healthy controls (P<0. 01). The level of serum MDAin MCI was significantly higher than that of elder healthy subjects (P<0. 01). Conclusions Free radical injury was included in the patho-physiological process of MCI. The early intervention of Vit E should be given in MCI.

关 键 词：老年 轻度认知功能损害 发病机制 氧自由基损伤 维生素E 超氧化物歧化酶 丙二醛 

分 类 号：R749.16[医药卫生—神经病学与精神病学]