人脑胶质瘤的流式细胞学研究及其临床意义  

The Flow Cytometric Study on Brain Gliomas and its Clinical Sign ificance

作　　者：邵君飞[1] 杨亚安[1] 张岩松[1] 

机构地区：[1]苏州大学附属第一医院,苏州215006

出　　处：《中国血液流变学杂志》2003年第4期310-312,共3页Chinese Journal of Hemorheology

摘　　要：目的　探讨人脑胶质瘤DNA倍体特性、细胞周期分布与肿瘤病理分级及其恶性程度的关系。方法　应用流式细胞学技术 (FCM)对 59例新鲜的脑胶质瘤组织标本进行FCM检测。结果　各型胶质瘤中的异倍体率、DNA指数 (DI)与其病理分级以及S期细胞比例 (SPF)与肿瘤恶性程度均存在着明显的相关性。结论　FCM能够直接反映肿瘤细胞的增殖活性 。Objective To investigate the relationship between DN A ploidy character, cell cycle distribution and histopathological grading, mali gnancy in gliomas.Method Flow cytometry was employed to stud y the fresh specimens from 59 cases of gliomas.Result Resu lt showed that the strong correlation between aneuploidy rate, DNA index(DI) an d histopathological grading,and also between S-phase fraction and malignancy in gliomas.Conclusion FCM detection can appraise the prolifera tive activity of gliomas directly and contribute to the estimation of tumor mal ignancy more accurately.

关 键 词：脑胶质瘤 流式细胞学 病理分级 恶性程度 

分 类 号：R739.41[医药卫生—肿瘤]