双黄补缓释药条治疗慢性牙周炎的临床研究  

Clinical study of shuanghuangbu delivery device in chronic periodontitis

作　　者：许彦枝[1] 刘健[1] 李伟[1] 王小玲[1] 刘世正[1] 

机构地区：[1]河北医科大学第四医院,石家庄050011

出　　处：《现代口腔医学杂志》2004年第1期46-49,共4页Journal of Modern Stomatology

基　　金：河北省科委资助课题 (编号 :0 2 2 7610 3D -19)

摘　　要：目的　评价局部应用双黄补缓释药条对控制牙周菌斑微生物及牙周炎症的作用。方法　选择中、重度慢性牙周炎患者 31例 ,采用同一口腔内病情相同牙齿的自身对照设计 ,将口腔内左右两侧共 12 0个受试牙位点配对分组。基线前须完成全口龈上洁治及口腔卫生宣教。基线时受试牙位点刮取龈下菌斑涂片 ,记录螺旋体比例 ,并记录探诊深度、附着丧失和探诊后出血等临床指数 ,然后行龈下刮治术 ,用药组每周放两次双黄补缓释药条 ,共放 4次 ,对照组不放药。第 14天和第 4 1天检查各项指数 (同基线 )。结果　用药组和对照组的各项临床指标、龈下菌斑中螺旋体比例均较基线时下降 ,且用药组下降程度更明显。结论　双黄补缓释药条可有效改善牙周菌斑微生物的组成 ,控制牙周炎症。Objective To evaluate the effect of scaling and root planing combined with local application of shuanghuangbu delivery device on subgingival periodontopathic microflora and periodontitis.Methods Thirty-one healthy adults with moderate to advanced chronic periodontitis participated in this study.This was a randomized,split mouth design study.The 120 target sites including left and right side were randomized into two groups.Subsequently the patients were scheduled for two appointments for the full-mouth supra-gingival scaling and oral hygiene instruction.At baseline subgingival plaque was sampled from each target sites for determining the percent of spirochetes.Three clinical parameters including probing depth,attachment loss and bleeding on probing were examined for each site.At baseline all the patients received subgingival scaling and root planning.The test group was followed by 4 time applications of shuanghuangbu with three day interval during totally two weeks,and no medicine was applied in the control group.At the 14 th and 41 st days,the examination was the same as the procedure of baseline.Results At the 14 th days the percent of coccoid cells significantly increased,and the percent of spirochetes was significantly decreased in the both groups.The test group exhibited greater differences than the control group.At the 41 st days,the percent of spirochete(S%) maintained the same level as that at the 14 th days in the test group,whereas S% in the control group rebounded.The test and the control group showed a decrease in probing denth(PD) and attachment loss(AL) At the 14 th and 41 st days,and the former produced a significant decrease in PD and AL compared with the latter.At the 14 th and 41 st days there was a significant decrease in bleeding on probing(BOP) (+)% in the test group compared with that at baseline.Whereas BOP(+)% At the 14 th and 41 st days and baseline showed no statistically significant differences in the control group.Conclusion Shu

关 键 词：双黄补缓释药条 药物治疗 慢性牙周炎 局部用药 中药 

分 类 号：R781.43[医药卫生—口腔医学]