绿脓杆菌菌毛制剂(佰安)免疫效能的实验研究  

The study of immune efficency to Bai-an

作　　者：刘惠萍[1] 郑曲波[1] 施理[1] 张宜俊[1] 

机构地区：[1]中国人民解放军第458医院全军肝病中心,广州510602

出　　处：《胃肠病学和肝病学杂志》2003年第6期572-574,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的　研究绿脓杆菌菌毛制剂 (佰安 )对机体的免疫刺激作用。方法　用流式细胞术检测佰安对慢性HBV感染者外周血树突状细胞 (DC)表面分子的影响以及佰安对T细胞的活化作用。结果　佰安在体外对CD11c+ 型DC的细胞数有促进作用 ,而与HBsAg联用后 ,其表达CD11c+ 、CD80 + 、CD86+ 型DC的细胞数增加更加显著。结论　佰安与HBsAg联用可增强DC的抗原提呈能力 ,活化T细胞 ,诱导细胞的免疫反应 。ObjectiveTo study the effect of Bai_an to t he immune system.MethodsThe expression of surface molecules on the peripheral blood dendritic cells(DC) from the patients chronic infected with HBV,treated by Bai_an was studied.ResultsBai_an stimulate d the expression of CD11c + of DCs.The effect significantly increases combinin g with HBsAg.ConclusionBai_an increase the antigen presenting function of D C,the active T lymphocyte cellular immune response was got,which suggest Bai_an would be the one of the drugs againse chronic infection of HBV.

关 键 词：绿脓杆菌菌毛制剂 免疫效能 流式细胞术 慢性乙型肝炎 外周血 树突状细胞 抗原提呈能力 

分 类 号：R979.5[医药卫生—药品] R512.62[医药卫生—药学]