心房颤动患者止凝血分子标志物的检测及意义  

Molecular markers of blood coagulation and hemostasis in patients with artrial fibrillation

作　　者：姜文清[1] 曹雁阁[1] 刘成伟[1] 

机构地区：[1]武汉钢铁集团公司第二职工医院内科,武汉430085

出　　处：《临床心血管病杂志》2004年第1期31-32,共2页Journal of Clinical Cardiology

摘　　要：目的 :观察心房颤动 (房颤 )患者血浆止凝血分子标志物的变化并探讨其临床意义。方法 :根据是否并发房颤将 4 5例心脏病患者分成房颤组 (n =2 1)与非房颤组 (n =2 4 ) ,另选 2 2例健康志愿者作为正常对照组 ,分别测定血浆血管性血友病因子、血浆α 颗粒膜蛋白、纤维蛋白原、抗凝血酶Ⅲ和D 二聚体含量 ,进行统计学分析。结果 :房颤组与非房颤组的各项指标与正常对照组比较差异均有统计学意义 (P <0 .0 1,P <0 .0 5 ) ,两者之间比较部分指标差异也有统计学意义 (P <0 .0 5 )。结论 :房颤患者处于血栓前状态 ,其体内存在多种促凝因素 。Objective: To investigate changes of plasma levels of the molecular markers of blood coagulation and hemostasis in patients with artrial fibrillation and to explore their clinical significances. Methods: Forty-five patients were divided into two groups according to having artrial fibrillation(AF) or not AF (NAF), 22 volunteers were composed of the control group. The plasma levels of vWF, GMP-140, FBG, AT-Ⅲ and D-Dimer of the subjects were measured in the three groups. Results: The plasma levels of these indexes in both the AF group and the NAF group were significantly differ from that of the control group(P< 0.01,P< 0.05). There were also differences in some indexes between the AF group and the NAF group (P< 0.05). Conclusion: There was a prothrombotic state(PTS) in patients with artrial fibrillation. A lot of factors might develop blood coagulation and result in artrial thrombogenesis eventually.

关 键 词：心房颤动 von WILLEBRAND因子 P-选择素 纤维蛋白原 抗凝血酶Ⅲ D-二聚体 止凝血分子标志物 检测 

分 类 号：R541.75[医药卫生—心血管疾病] R446.112[医药卫生—内科学]