川芎嗪对胰岛素抵抗大鼠急性局灶性脑缺血tPA,PAI,DD和ET-I含量的影响  

Protective Effect of Ligustrazine on Insulin Resistance after Local Cerebral Ischemia of Rat

作　　者：汪远金[1] 方正清[1] 王钦茂[1] 白玫[1] 马克龙[1] 

机构地区：[1]安徽中医学院中西医结合系,安徽合肥230038

出　　处：《中国中药杂志》2003年第12期1181-1183,共3页China Journal of Chinese Materia Medica

摘　　要：目的 :探讨川芎嗪对胰岛素抵抗 (IR)大鼠脑缺血的防护作用。方法 :采用电凝大脑中动脉致急性局灶性脑缺血模型、川芎嗪对IR急性局灶性脑缺血大鼠血浆组织型纤溶酶原激活物 (tPA)及其抑制物 (PAI)、D 二聚体 (DD)、内皮素 1(ET I)、超氧化物歧化酶 (SOD)和胰岛素敏感性指数 (IAI)变化。结果 :川芎嗪提高IAI(P <0 .0 1) ,PAI 1含量 (P <0 .0 1)和SOD活性 (P <0 .0 1) ,降低血浆tPA活性 (P <0 .0 1)、ET I含量 (P <0 .0 1)和DD含量 (P <0 .0 1)。结论 :川芎嗪对IR大鼠急性局灶性脑缺血具有防护作用是由于改善纤溶功能、降低ET I和增加SOD活性有关。Objective: To study the protective effect of Ligustrazine on IR after local cerebral ischemia of rat. Method:Models of rat IR after local cerebral ischemia were prepared by electrocagulation of the middle cerebral artery, and changes of serum insulin, tomer necrosis factor-alpha (TNF-α), plasma endothelin-1 (ET-1),nitric oxide(NO) and nitric oxide synthase(NOS) were observed 2 weeks after the ischemia. Result: Ligustrazine could significantly reduce serum insulin( P <0.01), the content of plasma ET-1( P <0.01) and serum TNF-α( P <0.01), the activity of brain tissue NO and NOS( P <0.01). The drug also increased insulin sensitivity indexes (ISI). Conclusion: The protective effects of Ligustrazion on IR cerebral ischemia may be related to decreasing ET-1 content in plasma, TNF-α content in serum, Nocontent and NOS activities in tissue.

关 键 词：川芎嗪 胰岛素抵抗 大鼠 急性局灶性脑缺血 TPA PAI DD ET-I 组织型纤溶酶原激活物 组织型纤溶酶原激活物抑制物 D-二聚体 内皮素-1 

分 类 号：R285.5[医药卫生—中药学]