白血病患者骨密度和血清骨代谢指标变化的临床研究  

CLINICAL RESEARCH ON THE VARIANCE OF BONE MINERAL DENSITY AND BONE METABOLISM OF LEUKEMIA PATIENTS

作　　者：孙达春[1] 张爱华[1] 李小亮[1] 吴红[1] 汪丽安[1] 赵玉成[1] 

机构地区：[1]珠海市人民医院,暨南大学医学院第三附属医院,广东珠海519000

出　　处：《白血病．淋巴瘤》2003年第6期354-356,共3页Journal of Leukemia & Lymphoma

基　　金：珠海市科研基金资助项目 ( 2 0 0 14 1)

摘　　要：目的 :探讨白血病患者骨密度和骨代谢状态的变化。方法 :采用双能 X线骨密度仪(DEXA)测量 4 5例 AL (A1 组 ) ,7例 CR者 (A2 组 )和 1 5例 CML (A3组 )患者骨密度 (BMD) ,同时采用放射免疫法测定血清骨钙素 (BGP) , 型胶原羧基末端肽 (ICTP)水平 ,并与 2 0名正常人 (B组 )作对照。结果 :A1 组 L2 ～ L4 BMD下降 (P<0 .0 1～ 0 .0 0 1 ) ;A2 组 L3BMD下降 (P<0 .0 5 ) ;A3组 L3、L4BMD下降 (P<0 .0 5 )。 A1 组 BGP、ICTP均升高 (P<0 .0 5 ) ,A3组 ICTP升高 (P<0 .0 5 )。结论 :白血病患者 L2 ～ L4 骨密度下降 。Objective:To investigate the variance of bone mineral density and bone metabolism of leukemia patients.Methods:Double energy X ray absorptiometry (DEXA) was employed to detect the bone mineral density (BMD) of 45 AL (A 1 group), 7 CR (A 2 group), 15 CML (A 3 group) and 20 healthy control, blood serum Osteocalcin (BGP) and serum carboxy terminal collagen telopeptide (ICTP) were assayed by radio immunity.Results: In A 1 group L 2～L 4 BMD decreased significantly ( P <0.01～0.001); in A 2 group L 3 and A 3 group L 3, L 4 BMD decreased significantly ( P <0.05) ; BGP , ICTP increased significantly in A 1 group ( P <0.05) , ICTP increased significantly in A 1 group ( P <0.05).Conclusion:In leukemia patients L 2～L 4, the bone mineral density decreased and in AL the transforming of bone was accelerated.

关 键 词：白血病 骨密度 骨钙素 Ⅰ型胶原羧基末端肽 骨代谢 

分 类 号：R733.7[医药卫生—肿瘤] R68[医药卫生—临床医学]