骨肿瘤治疗剂^(90)Y-EDTMP的研究  

PREPARATION OF ^(90)Y-EDTMP FOR BONE TUMOR TREATMENT

作　　者：杨志[1] 金小海[1] 于海宾[1] 白素珍 姜士杰[2] 孟昭兴[2] 杨雷[2] 魏学雅[2] 田爱平[2] 

机构地区：[1]中国原子能科学研究院,北京102413 [2]空军总医院核医学科,北京100036

出　　处：《同位素》1992年第2期72-77,共6页Journal of Isotopes

摘　　要：介绍了一种用于骨肿瘤治疗的放射性药物^(90)Y-EDTMP的合成和放射性标记方法。同时系统地对标记介质的pH、反应时间、EDTMP用量和反应温度进行了研究。经动物实验和临床初步观察表明,本药物在骨中高度浓集,可以与国产^(90)Y发生器配套成药盒供临床使用。Syntheses of EDTMP preparation and ^(99)Y-labelling of radiopharmaceutical ^(99)Y-EDTMP used for the treatment of bone tumor were reported. The dependence of the labelling efficiency on pH me dium, reaction times, temperature and quantities of EDTMP was systematically investigated. Animal tests and preliminary clinicaltrials showed that the labelled compound might be used for clinical treatment of bone tumor.

关 键 词：放射性药物 肿瘤 骨 标记 钇90 

分 类 号：R730.55[医药卫生—肿瘤]