Microtetraspora sp转化美伐他汀至普伐他汀发酵条件的研究  

Study on Fermentation Condit ions of Converting Mervastatin to Pravastatin by Microtetraspora sp

作　　者：周鹃 范贵增[2] 黄筱萍[2] 印培民[2] 

机构地区：[1]江西省药品检验所,南昌330046 [2]江西省科学院微生物研究所,南昌330029

出　　处：《江西医药》2003年第6期406-408,共3页Jiangxi Medical Journal

摘　　要：小四孢菌(Microtetrasporasp)在不同的转化培养基和培养条件下,转化美伐他汀(Mevastatin)为普伐他汀(Pravastatin)。在转化培养基A,初始底物浓度为500mg/L时,摇瓶发酵7d,转化率为50.14%,Pravastatin产量达260mg/L;在3L发酵罐中间歇补加底物和1～4g/L葡萄糖,培养11d,Pravastatin产量达375mg/L,转化率为45.2%。Pravastatin was converted from Mervas-tatin on the different media and fermentation con-ditions by Microtetraspora sp.260mg Pravastatin/L and50.14%conversion rate was obtained at7days flasker incubation with initial500mg Mervastatin/L.It yielded375mg Pravastatin/L and getted conver-sion rate45.2%at11days jar fermentation with the intermittently adding Mevastatin and14g glu-cose /L.

关 键 词：Microtetrasporasp 转化 美伐他汀 普伐他汀 发酵条件 研究 小四孢菌 

分 类 号：TQ460.38[化学工程—制药化工]