缬沙坦和培哚普利对大鼠肝纤维化模型肠通透性的影响  

Effects of valsortan and perindopril on hepatic fibrosis and their influences on intestinal permeability

作　　者：阮鹏[1] 张全荣[1] 龚作炯[1] 

机构地区：[1]武汉大学病毒学教育部重点实验室,武汉大学人民医院感染科430060

出　　处：《肝脏》2003年第4期31-33,共3页Chinese Hepatology

摘　　要：目的　观察血管紧张素受体阻滞剂缬沙坦和血管紧张素转换酶抑制剂培哚普利对四氯化碳诱导大鼠肝纤维化模型的疗效及对其肠通透性的影响。方法　将大鼠分为A组 (正常对照组 )、B组 (模型对照组 )、C组 (缬沙坦治疗组 )和D组 (培哚普利治疗组 ) ,于造模第 4周C组开始用缬沙坦 ( 10mg/kg) ,D组开始用培哚普利 ( 0 .5mg/kg)治疗 ,共 4周 ,进行肝组织及小肠组织苏木精 伊红染色 ,检测血浆D 乳酸、DAO和内毒素浓度。结果　经治疗后肝纤维化大鼠肝小叶结构趋于正常 ,纤维间隔变薄 ,血浆D 乳酸、DAO和内毒素浓度下降。结论　培哚普利和缬沙坦能有效地减轻四氯化碳诱导肝纤维化大鼠的损伤及纤维化程度 ,减轻肠源性内毒素血症和肠通透性增加。Objective To investigate the effects and mechanism of angiotensin receptor blocker valsortan and angiotensin-converthing enzyme inhibitor perindopril in rats with liver fibrosis induced by carbon tetrachloride(CCl 4) and their influences on intestinal permeability. Methods 38 Wistar rats were divided into four study groups:(1) healthy controls, (2) CCl 4 injured rats' untreated, (3) CCl 4 injured rats treated with valsortan,(4) CCl 4 injured rats treated with perindopril. Valsortan and perindopril were given once daily respectively. After administration for 4 weeks, the rats were killed. The histopathology of the liver and the intestine were observed by HE staining.Plasma endotoxin,D-lactate, diamine oxidase levels were determined by spectrophotometer.Results The structure of hepatic lobules improved greatly, the fibrous septa became thinner in the treated rats. The plasma levels of endotoxin,D-lactate and diamine oxidase decreased significantly also in the treated rats(P<0.05 or P<0.01).Conclusion Valsortan and perindopril can inhibit liver fibrosis induced by CCl 4 in rats,and can prevent endotoxemia and gut failure.

关 键 词：缬沙坦 培哚普利 大鼠 肝纤维化 动物模型 肠通透性 

分 类 号：R575.2[医药卫生—消化系统] R972.4[医药卫生—内科学]