可溶性喉鳞癌抗原和抗CD_3单抗及r1L-2共同诱导的杀瘤细胞—TAK细胞的杀瘤机制的研究  

THE STUDIES ON THE MECHANISM OF THE SOLUBLE TUMOR ANTIGEN ACTIVATED KILLER(TAK) CELLS AGAINST THE Hep-2 CELL LINES

作　　者：杨海良[1] 屠规益[1] 李庆宏[1] 唐平章[1] 陈毓仙[1] 

机构地区：[1]中国协和医科大学

出　　处：《临床肿瘤学杂志》1996年第3期1-3,共3页Chinese Clinical Oncology

摘　　要：作者在前期研究工作的基础上,进一步探讨喉鳞癌抗原诱导的TAK细胞的杀瘤机理。结果表明:TAK细胞除直接杀伤靶细胞外,还通过分泌肿瘤坏死因子间接杀伤靶细胞。电镜观察表明,靶细胞的死亡形式有两种:溶解坏死和凋亡。The mechanisms of TAK cells to kill the laryngeal squamous cell carcinoma cell lines Hep-2 included the direct and indirect cytotoxicity. The former led the Hep-2 cells to lytic necrosis. The latter induced the programmed cell death of the Hep-2 cells(Apoptosis) by the secretion of cytokines such as tumor necrotic factor(TNF) which was from the cultural supernatants of TAK cells.

关 键 词：可溶性喉鳞癌抗原 TAK细胞 杀瘤机制 癌细胞 

分 类 号：R739.65[医药卫生—肿瘤]