乌拉地尔和枢丹对伤害性刺激大鼠脊髓镇痛的电生理研究  

A Electric-physiologic Study of Urapidil and Ondansetron on Analgesia of Spinal Level in Rats

作　　者：孙宝春 贡祥林 秦正敏 

机构地区：[1]江苏大学附属镇江市第一人民医院麻醉科,江苏镇江212002

出　　处：《江苏大学学报（医学版）》2003年第6期491-493,共3页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:通过乌拉地尔和枢丹影响大鼠脊髓神经电生理的观察,进行其对比性研究。方法:24只Wistar大鼠随机分为生理盐水组、0.5％乌拉地尔组、0.08％枢丹组、乌拉地尔和枢丹复合用药组,于坐骨神经行电刺激,在脊髓近心端记录其复合动作电位。结果:0.5％乌拉地尔组与生理盐水组相比,脉冲电压的幅度改变及传导时程的改变显著(P<0.05);0.08％枢丹组与盐水对照组和0.5％乌拉地尔组相比相差不显著(P>0.05);乌拉地尔和枢丹复合用药组与生理盐水组相比(P<0.05),差异显著,和0.08％枢丹组与0.5％乌拉地尔组相比,差异不显著(P>0.05)。结论:乌拉地尔在脊髓水平上抑制神经冲动的传导,枢丹无此作用,两药合用也无相加作用。Objective: By observation of the electric-physiology of spinal cord in rats,to have the contrast study of analgesia on spinal cord for urapidil and ondansetron. Methods: Twenty four Wistar s rats were classified into 4 sets: saline, urapidil, ondansetron, urapidil plus ondansetron. With stimulating the sciatic nerve, the compound action potential on near-heart tip of spinal cord was recorded. Results: Comparing urapidil with saline, the difference in range of the compound action potential and the time of nerve's electric conduction is significant (P<0.05) ; ondansetron with saline or urapidil, the difference is insignificant(P>0. 05) ; urapidil plus ondansetron compares with saline, the difference is significant( P<0. 05) , while it was insignificant with ondansetron or urapidil, (P>0.05). Conclusion: Urapidil can restrain the conduction of nerve's impulse on the spinal cord, but ondansetron has no this effect, and association with urapidil and ondansetron didn't increase the inhibiting intensity. This illustrated there was no additive effect for this two drugs.

关 键 词：乌拉地尔 枢丹 脊髓镇痛 伤害性刺激 电生理 

分 类 号：R-33[医药卫生]