EB病毒与食管癌相关性的研究  

The Relationship between EB Virus and Esophageal Carcinoma

作　　者：张建武[1] 王卫萍[2] 陈亚利[2] 徐肇敏[1] 陈隆典[1] 张志宏[1] 

机构地区：[1]南京大学医学院附属鼓楼医院消化科.南京210008 [2]南京军区南京总医院检验科

出　　处：《江苏大学学报（医学版）》2003年第6期498-499,共2页Journal of Jiangsu University：Medicine Edition

摘　　要：目的:探讨EB病毒与食管癌发生的关系。方法:用双温聚合酶链反应(PCR)扩增出EB病毒Bam W区的121bpDNA片段,用此法对89份食管肿瘤和非肿瘤的胃镜活检标本进行了EB病毒DNA检测。结果:食管癌胃镜活检组织中EB病毒阳性率6.3％(3/48),10例癌旁、远离癌灶5 cn以上食管组织和21例非肿瘤病变均阴性。结论:食管癌活检组织中EB病毒感染率低,两者关系的进一步研究,有助于EB病毒致瘤机制的阐明。Objective: To study the relationship between EB virus and esophageal carcinoma. Methods: EB virus DNA was examined by two temperature polymerase chain reaction cycles from 89 biopsy tissues with different esophageal lesions. The amplified product 121 bp DNA was in EB virus Bam W zone. Results: The EB virus infection postive rate was 6.3% (3/48) for esophageal carcinoma, the control was all EB virus DNA negative. Conclusion: The EB virus infection positive rate was low in esophageal carcinoma. The relationship between EB virus and esophageal carcinoma is to be investigated further.

关 键 词：食管癌 EB病毒 聚合酶链反应 

分 类 号：R735.1[医药卫生—肿瘤]