川芎嗪对肝缺血-再灌注损伤时黄嘌呤氧化酶活性的影响  

Effect of ligustrazini(川芎嗪) on xanthine oxidase activity during hepatic ischemia/reperfusion injury

作　　者：王万铁[1] 林丽娜[2] 王卫[1] 徐正祄[1] 李东[3] 

机构地区：[1]温州医学院病理生理学教研室,浙江温州325027 [2]温州医学院附属第一医院麻醉科,浙江温州325003 [3]温州医学院检验系分析中心,浙江温州325027

出　　处：《中国中西医结合急救杂志》2003年第6期340-342,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：浙江省跨世纪学术和技术带头人培养基金(992086);温州市"551人才工程"培养基金(98018);浙江省卫生厅科研基金(98A087);浙江省教育厅科研基金(951118)

摘　　要：目的 :探讨川芎嗪 (L GT)对肝缺血再灌注损伤 (HIRI)时黄嘌呤氧化酶 (XO)活性的影响。方法 :选择 HIRI实验兔及肝癌手术患者 ,动态观察血浆 XO活性的变化及 L GT对它的影响。结果 :HIRI期间 ,血浆及肝组织内 XO活性明显增强 (P<0 .0 5和 P<0 .0 1) ;使用 L GT后 ,XO活性的异常变化显著减轻 ,其差异有显著性意义 (P<0 .0 5和 P<0 .0 1)。结论 :L GT可有效地抑制 HIRI时 XO活性而减少氧自由基的形成。Objective: To explore the effect of ligustrazini (川芎嗪,LGT) on xanthine oxidase (XO) activity during hepatic ischemia/reperfusion injury (HIRI). Methods: HIRI model in rabbits was used. Rabbits were randomly divided into three groups(n=10) and patients with liver cancer were randomly divided into two groups(n=9). The dynamic changes of XO activity in plasma and the effect of LGT on it were observed during HIRI in 30 rabbits and 18 patients who were scheduled for selective hepatic surgery. Results: XO activity significantly increased (P<0.05 and P<0.01) in the plasma and liver tissue during HIRI. After treatment of LGT, the abnormal change of the XO activity was alleviated remarkably and there were significant differences (P<0.05 and P<0.01) about XO activity in the plasma and liver tissue. Conclusion: These date suggest that LGT can effectively inhibit XO activity and decrease the formation of oxygen free radicals during HIRI.

关 键 词：川芎嗪 肝缺血 再灌注损伤 黄嘌呤氧化酶 氧自由基 

分 类 号：R285.5[医药卫生—中药学] R256.4[医药卫生—中医学]