Anticancer Activities of Substituted Cinnamic Acid Phenethyl Esters on Human Cancer Cell Lines  

取代肉桂酸苯乙酯的抗肿瘤活性研究(英文)

作　　者：李树春[1] 李辉[1] 张法[1] 李中军[1] 崔景荣[2] 

机构地区：[1]北京大学药学院化学生物学系 [2]北京大学天然药物及仿生药物国家重点实验室，北京10008

出　　处：《Journal of Chinese Pharmaceutical Sciences》2003年第4期184-187,共4页中国药学（英文版）

基　　金：NationalScienceFoundationofChina(3 0 0 70 887)

摘　　要：Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB assay on six different human cancer cell lines. The results indicated that in the concentration of 10 μmol·L -1 the lead compound CAPE possessed anticancer activities against human HL 60, Bel 7402, and Hela cell lines, and two other compounds possessed potent anticancer activities against Bel 7402 and Hela cell lines.Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB assay on six different human cancer cell lines. The results indicated that in the concentration of 10μmol·L^-1 the lead compmuM CAPE possessed anficancer activities against human HL-60, Bel-7402, and Hela cell lines, and two other compounds possessed potent anticancer activities against Bel-7402 and Hela cell lines.

关 键 词：medicinal chemistry cinnamic acid phenethyl esters chemical synthesis anticancer activity 

分 类 号：R979.1[医药卫生—药品]