李树春

作品数:8被引量:19H指数:3
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供职机构:北京大学更多>>
发文主题:簇化合物寡糖化学合成方法化合物芒果苷更多>>
发文领域:医药卫生化学工程理学轻工技术与工程更多>>
发文期刊:《中国药物化学杂志》《Journal of Chinese Pharmaceutical Sciences》更多>>
所获基金:国家自然科学基金国家重点基础研究发展计划全国教育科学“十五”规划国家一般课题更多>>
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Theβ-directing effect of ionic liquid in mannopyranosylation:a potential access to stereoselective construction of the 1,2-cis-β-D-mannopyranosyl linkage
《Journal of Chinese Pharmaceutical Sciences》2011年第6期549-556,共8页孙晟 马庆 孟祥豹 李庆 李树春 黄河清 李中军 
National Natural Science Foundation of China (Grant No.20732001) ;the State New Drug Innovation(the Ministry of Science and Technology of China,Grant No. 2009ZX09501-011)
We report a novel P-directing effect of imidazolium based ionic liquid,which was observed when we conducted the glycosylation of a 6-O-acetyl-2,3,4-tri-O-benzyl-mannose trichloroacetimidate donor with a modified ionic...
关键词:Ionic liquid supported strategy GLYCOSYLATION STEREOSELECTIVITY 
Synthesis of two multivalent lactosides with anti-adhesive activity and their fluorescein-labeled and biotin-labeled derivatives被引量:1
《Journal of Chinese Pharmaceutical Sciences》2011年第4期325-334,共10页李庆 赵岳涛 孟祥豹 严婷婷 李树春 黄河清 赵智辉 李中军 
National Natural Science Foundation of China (Grant No 90713004);Ministry of Science and Technology of China(Grant No.2009ZX09103044.2009ZX09301-010)
Adhesion of leukocytes to endothelium plays an important role in inflammation-associated diseases.Our previous studies showed that multivalent lactosides were able to inhibit this process.Using 2-azide-l,3-propandiol ...
关键词:ANTI-ADHESION BIOTIN FLUORESCEIN Multivalent-lactosides Synthesis 
Synthesis of a series of guanidine substituted derivatives of aminoglycosides
《Journal of Chinese Pharmaceutical Sciences》2011年第2X期133-138,共6页彭勃 陈桂辉 潘攀 孟祥豹 黄河清 李树春 李中军 
National Basic Research Program(973 Program, Grant No.2004CB518904);the State New Drug Innovation (Grant No.2009ZX09301-010,2009ZX09103 -044).
A novel method to prepare guanidine substituted aminoglycoside derivatives was developed.Free guanidine reacted with Cbz-protected aminoglycosides to produce guanidinylcarbonyl substituted derivatives.A methoxycarbony...
关键词:AMINOGLYCOSIDE Cbz SUBSTITUTED GUANIDINE Antibacterial activities 
有机化学实验教学改革与高素质人才培养探索被引量:2
《医学教育》2005年第5期60-61,共2页黄河清 李树春 孟祥豹 刘俊义 李中军 
全国教育科学"十五"国家规划课题子项目5:21世纪中国高等学校医药类专业化学基础课程的创新与实践
作为医药学教育重要的基础课程,有机化学实验教学对于培养高素质医药学人才的创新能力具有重要的作用。本文对近2年来所实施的有机化学实验教学改革的尝试和探索进行了总结。
关键词:有机化学实验 教学模式 改革与创新 人才培养 
钙拮抗剂拉西地平的合成新工艺被引量:4
《中国药物化学杂志》2004年第6期365-367,共3页黄河清 李树春 王安邦 蔡孟深 李中军 
目的完成钙拮抗剂拉西地平合成的新工艺。方法以邻苯二甲醛、β 氨基巴豆酸乙酯、三苯基亚膦基乙酸叔丁酯为原料 ,采用常规的化学合成法合成。结果采用先形成二氢吡啶环 ,再通过Wittig反应制备烯烃双键的顺序 ,拓展了拉西地平合成的新...
关键词:药物化学 工艺改进 化学合成 钙拮抗剂 拉西地平 
Synthesis of Phenylpropanoid Glycoside Analogs被引量:1
《Journal of Chinese Pharmaceutical Sciences》2004年第1期14-18,共5页李树春 周静 李中军 
NationalNaturalScienceFoundationofChina( 30 0 70 887)
The regioselective acylation of unprotected phenylethyl glucoside withcinnamoyl chloride leads to 6-OH cin-namoylated glucoside. In this manner, thirteen phenylpropanoidglycoside analogs were designed and prepared. Th...
关键词:medicinal chemistry regioselective acylation phenylpropanoid glycoside glycoside analogs chemical synthesis 
新型抗心绞痛药雷诺嗪的合成研究被引量:7
《中国药物化学杂志》2003年第5期283-285,共3页李树春 黄河清 李中军 
目的合成新型抗心绞痛药雷诺嗪。方法以邻甲氧基苯酚、环氧氯丙烷、2,6-二甲基苯胺、哌嗪为原料,采用常规的化学合成法。结果通过优化条件以较高的收率合成雷诺嗪二盐酸盐。结论用元素分析、质谱、氢谱、碳谱等鉴定了目标物的结构。优...
关键词:药物化学 工艺改进 化学合成 抗心绞痛药 雷诺嗪 
Anticancer Activities of Substituted Cinnamic Acid Phenethyl Esters on Human Cancer Cell Lines被引量:4
《Journal of Chinese Pharmaceutical Sciences》2003年第4期184-187,共4页李树春 李辉 张法 李中军 崔景荣 
NationalScienceFoundationofChina(3 0 0 70 887)
Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB...
关键词:medicinal chemistry cinnamic acid phenethyl esters chemical synthesis anticancer activity 
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