National Natural Science Foundation of China (Grant No.20732001) ;the State New Drug Innovation(the Ministry of Science and Technology of China,Grant No. 2009ZX09501-011)
We report a novel P-directing effect of imidazolium based ionic liquid,which was observed when we conducted the glycosylation of a 6-O-acetyl-2,3,4-tri-O-benzyl-mannose trichloroacetimidate donor with a modified ionic...
National Natural Science Foundation of China (Grant No 90713004);Ministry of Science and Technology of China(Grant No.2009ZX09103044.2009ZX09301-010)
Adhesion of leukocytes to endothelium plays an important role in inflammation-associated diseases.Our previous studies showed that multivalent lactosides were able to inhibit this process.Using 2-azide-l,3-propandiol ...
National Basic Research Program(973 Program, Grant No.2004CB518904);the State New Drug Innovation (Grant No.2009ZX09301-010,2009ZX09103 -044).
A novel method to prepare guanidine substituted aminoglycoside derivatives was developed.Free guanidine reacted with Cbz-protected aminoglycosides to produce guanidinylcarbonyl substituted derivatives.A methoxycarbony...
The regioselective acylation of unprotected phenylethyl glucoside withcinnamoyl chloride leads to 6-OH cin-namoylated glucoside. In this manner, thirteen phenylpropanoidglycoside analogs were designed and prepared. Th...
Caffeic acid phenethyl ester (CAPE) and sixteen substituted cinnamic acid phenethyl esters were prepared via conventional procedures in order to test their in vitro anticancer activities by either MTT assay or SRB...