Introduction: Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a neuroregressive disorder associated with subacute encephalopathy, confusion, dysarthria, and dysphagia, as well as occasional external ophtha...
the National Natural Science Foundation of China(Nos.22177089,21721005,92153303,22037004,22177088);the Fundamental Research Funds for the Central Universities(2042021kf0211);Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNJC202309).
DNA 5-formylcytosine(5fC)is a prominent epigenetic modification within biological systems.Recent investigations have shed light on its pivotal role in governing cell fate,gene expression,and disease pathways.However,o...
Dear editor,Dysregulated inflammatory responses primarily account for damage to the central nervous system,however,neurodegenerative processes likely contribute to the pathophysiology of progressive forms of multiple ...
supported by the National Key R&D Program of China(No.2017YFA0505400);the National Natural Science Foundation of China(Nos.21877024,21972214 and 22277020)。
Activity-based Ubiquitin probes(Ub-ABPs)carrying a reporter group have emerged as effective tools for the investigation of deubiquitinating enzymes(DUBs),such as studying the molecular mechanism of DUBs,profiling new ...
This work aims to prepare chitosan(CS)-based coated layers,CS(10 wt%nanosilver/90 wt%CS,10 wt%biotin/90 wt%CS,and 5 wt%nanosilver–5 wt%biotin)/90 wt%CS coatings are prepared,onto pure Ti substrate.The surface morphol...
This work was supported by the National Natural Science Foundation of China(Project 31871967);High-tech R&D Program of Liaoning(Project 2019JH2/10200012);High-Level Talent Support Foundation from Liaoning,Shenyang and Shenyang Agricultural University(Project XLYC1902104,RC180025 and 880418001)and Natural Science Foundation of Liaoning(20180550214);The authors thank Professor Shu-Sheng Liu for providing us with the whitefly B.tabaci MEAM1 culture,and thank Professor Chuan-Xi Zhang for providing us with the brown planthopper N.lugens culture,Dr.Yu-Ting Li,Yan-Bin Wang,Xiao-Rui Xu for help with experiments.
Dear Editor,As the coenzyme of multiple carboxylases,biotin plays key roles in intermediary metabolism and animal nutrition(Listed 1990;Douglas,2017).Therefore,the analytical determination of biotin levels in diverse ...
This work details a newly developed“sandwich”nanoplatform via neutravidin-biotin system for the detection and treatment of inflammation.First,biotinylated-and folate-conjugated optical imaging micelles targeted acti...
supported by Anhui Scientific and Technological Project(No.1704a0802164);the Natural Science Foundation of the Anhui Higher Education Institutions of China(No.KJ2018A0192)
Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we ration...
The rupture force of the streptavidin-biotin complex was investigated using atomic force microscopy (AFM). The most frequently observed rupture force (MFOF), which is essential for the evaluation of the potential land...
Supported by the National Natural Science Foundation of China(No. 81572082) and the Natural Science Foundation of Jilin Province, China(Nos.2011713, 20150414015GH, 20150204010YY).
The effect of the chelating agent 4,7-bis(chlorosulfophenyl)-1,10-phenanthroline-2,9-dicarboxylic acid (BCPDA) labeled hepatitis B surface antibodies(HBsAb) on time-resolved fluoroimmunoassays(TRFIA) was inves...