A pretargeting nanoplatform for imaging and enhancing anti-inflammatory drug delivery  

作　　者：Min Kyung Khang Jun Zhou Cynthia M.Co Shuxin Li Liping Tang 

机构地区：[1]Department of Chemistry and Biochemistry,University of Texas at Arlington,700 Planetarium Place,Chemistry Physics Building Room 130,Arlington,TX,76019-0065,USA [2]Department of Bioengineering,University of Texas at Arlington,Engineering Research Building,Room 226,Box 19138,Arlington,TX,76010,USA

出　　处：《Bioactive Materials》2020年第4期1102-1112,共11页生物活性材料（英文）

摘　　要：This work details a newly developed“sandwich”nanoplatform via neutravidin-biotin system for the detection and treatment of inflammation.First,biotinylated-and folate-conjugated optical imaging micelles targeted activated macrophages via folate/folate receptor interactions.Second,multivalent neutravidin proteins in an optimal concentration accumulated on the biotinylated macrophages.Finally,biotinylated anti-inflammatory drug-loaded micelles delivered drugs effectively at the inflammatory sites via a highly specific neutravidin-biotin affinity.Both in vitro and in vivo studies have shown that the“sandwich”pretargeting platform was able to diagnose inflammation by targeting activated macrophages as well as improve the therapeutic efficacy by amplifying the drug delivery to the inflamed tissue.The overall results support that our new pretargeting platform has the potential for inflammatory disease diagnosis and treatment.

关 键 词：Polymeric micelles Neutravidin/biotin system PRETARGETING MACROPHAGES DEXAMETHASONE Inflammatory responses 

分 类 号：R318[医药卫生—生物医学工程]