Streptavidin-Biotin Complexes as Tools for Modulating an Important DNA Episgenetic Modification  

作　　者：Yongjie Liu Xinyan Xu Xingyu Liu Wei Xiong Qianqian Qi Yuanyuan Zhang Jinxuan Hou Tian Tian Xiang Zhoua 

机构地区：[1]Key Laboratory of Biomedical Polymers of Ministry of Education,College of Chemistry and Molecular Sciences,Hubei Province Key Laboratory of Allergyand Immunology,Wuhan University,Wuhan,Hubei 430072,China [2]Department of Thyroid&Breast Surgery,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan,Hubei 430072,China

出　　处：《Chinese Journal of Chemistry》2024年第18期2166-2172,共7页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(Nos.22177089,21721005,92153303,22037004,22177088);the Fundamental Research Funds for the Central Universities(2042021kf0211);Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(Grant No.ZNJC202309).

摘　　要：DNA 5-formylcytosine(5fC)is a prominent epigenetic modification within biological systems.Recent investigations have shed light on its pivotal role in governing cell fate,gene expression,and disease pathways.However,our comprehension of the precise control of the 5f site structure to influence its functionality remains limited.In this study,we have successfully achieved precise control over 5fc activity by harnessing the interaction between streptavidin and biotin.This research underscores the potential application of interactions between biomacromolecules and small molecules in advancing the field of DNA epigenetic functional regulation.

关 键 词：Epigenetic modification BIOTIN STREPTAVIDIN SELECTIVITY REGULATION 

分 类 号：O64[理学—物理化学]