急性胰腺炎血清IL-18的动态变化及临床意义  

Clinical Significance and Dynamic Changes of Serum IL-18 in Acute Pancreatitis

作　　者：王? 邓明明[1] 唐川康[1] 

机构地区：[1]泸州医学院附属医院消化内科,泸州646000

出　　处：《中国临床医学》2003年第6期823-825,共3页Chinese Journal of Clinical Medicine

摘　　要：目的 :检测AP患者血清IL - 18的浓度变化 ,探讨其可否作为AP严重程度 (尤其是ARDS是否发生 )的早期预测指标。方法 :89例AP患者分为AEP、AHNP无ARDS和AHNP并ARDS 3组 ,30例健康者为对照 ,采用ELISA法检测IL - 6、IL - 18,免疫扩散法检测CRP。结果 :AHNP(无论有无ARDS)血清IL - 6、IL - 18、CRP浓度明显高于AEP和对照组 ;AEP明显高于对照组 ;在并发ARDS的AHNP与无ARDS的AHNP ,IL - 6、CRP浓度无明显差异 ,但前者IL - 18浓度明显高于后者 (P <0 .0 1)。结论 :IL - 18不仅可预测AP严重程度 ,而且可预测是否发生ARDS。Objective: To evaluate serum IL-18 concentrations and assess whether it was regarded as a marker of predicting severity and ARDS complication in acute pancreatitis(AP). Methods: 89 patients with AP were divided into AEP and AHNP,AHNP were divided into with and without ARDS. serum IL-6,IL-18 were determined by ELISA,CRP was determined by immunodiffusion in all patients and 30 healthy volunteers. Results: The values of IL-6?IL-18?CRP were AHNP(with or without)>AEP>control, there were significant differences in levels of IL-6?IL-18?CRP among AEP?AHNP(with or without) and control; there were significant differences in levels of IL-18 but not IL-6?CRP for patients with ARDS versus without ARDS. Conclusion:Serum IL-18 values may not only represent another early marker indicating severe course of AP, but also a marker predicting ARDS.

关 键 词：急性胰腺炎 血清 IL-18 动态变化 成人呼吸窘迫综合征 

分 类 号：R576[医药卫生—消化系统]