文拉法辛与三环类抗抑郁药物治疗抑郁症副作用的循证医学研究  

Evidence-based medicine study on side effects of venlafaxine and tricyclic antidepressants in treatment of depression

作　　者：金卫东[1] 钱敏才 胡纪明 冯斌[1] 

机构地区：[1]浙江省立同德医院,浙江省精神卫生研究所,杭州311122 [2]浙江省湖州市第三医院,湖州313000 [3]浙江省金华市第二医院,金华321000

出　　处：《循证医学》2003年第4期215-218,共4页The Journal of Evidence-Based Medicine

摘　　要：目的 比较文拉法辛与三环类抗抑郁药物治疗抑郁症临床副作用的差异。方法 应用循证医学的Meta分析,采用固定效应模型法对符合标准的15项对照研究文献进行评价。结果 文拉法辛与三环类抗抑郁药物治疗抑郁症的副作用出现率不同,大多数的副作用之间差异有显著性(x2=8.13～91.93,df=1,P=0.00;综合的ORs=0.16～0.28,95％CI 0.06～0.68)。而两种药物的副作用头痛、恶心呕吐、焦虑失眠没有差异。结论 文拉法辛与TCA治疗抑郁症的副作用是有差别的。Objective To compare the difference in rate of side effects of depression patients treated with venlafaxine and tricyclic antidepressants (TCA). Method The 15 standard articles published were analyzed by fixed effects model, meta-analysis of evidence-based medicine (EBM). Results The significant difference in the rate of most side effects between venlafaxine and tricyclic antidepressants was found (x2=8.13-91.93 ,df-1 ,P=0.00). Comprehensive ORS was 0.16-0.28,with 95%CI 0.06~0.68. No differences in the rate of headache, vomiting, anxiety and insomnia between venlafaxine and TCA were found. Conclusion The results suggested that venlafaxine is characterized by lower rate of most side effects than tricyclic antidepressants in treatment of depression.

关 键 词：文拉法辛 抗抑郁药物 治疗 抑郁症 副作用 循证医学 SSRI 精神学科 

分 类 号：R749.4[医药卫生—神经病学与精神病学]