电刺激大鼠束旁核对丘脑腹内侧核神经元放电的影响  

Effect of Electrical Stimulation of the Parafascicular Nucleus on the Neuronal Activities of the Ventromedial Nucleus in Rats

作　　者：林凡凯[1] 辛艳[2] 高东明[1] 侯瑞鹏[3] 

机构地区：[1]锦州医学院生理学教研室 [2]锦州医学院药学院 [3]锦州医学院解剖学教研室,辽宁锦州121001

出　　处：《锦州医学院学报》2003年第5期10-13,共4页Journal of Jinzhou Medical College

摘　　要：目的　研究电刺激大鼠丘脑束旁核 (PF)对丘脑腹内侧核 (VM)神经元放电的影响 ,为临床高频刺激PF治疗帕金森氏病提供电生理学依据。方法　应用细胞外记录的方法观察不同频率电刺激 (强度 0 4mA ,波宽0 1ms ,时程 5S ,频率 1、 10、 2 0、 5 0、 10 0、 130、 2 0 0Hz)大鼠丘脑束旁核时丘脑腹内侧核神经元放电的变化。结果　高频刺激 (130Hz)PF可使大多数VM神经元的放电频率较刺激前明显增加 (P <0 0 1) ,该作用具有频率依赖性。结论　高频刺激大鼠PF对VM主要为兴奋作用 。Objective To research the effect of the electrical stimulation of the parafascicular nucleus(PF)on the neuronal activities of the ventromedial nucleus (VM) in rats.Methods Electrical stimulation(width 0.1ms,intensity 0.4mA,duration 5s,frequency 1,10,20,50,100,130,200Hz)was delivered to the PF. The firing rates of VM neurons were observed by extracellular recording.Results The majority of the VM neurons showed asignificant increase of the discharge rates in response to high-frequency stimulation of the PF(P<0.01),this effect was in a frequency-dependent manner.Conclusions High-frequency stimulation of the PF induced an excitatory effect on the spontaneous activity of the VM neurons in normal rats.It suggests that PF HFS should be an effective surgical procedure for the treatment of Parkinsonian motor symptoms.

关 键 词：电刺激 大鼠 束旁核 丘脑腹内侧核 神经元放电 帕金森氏病 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R454.1[医药卫生—临床医学]