原发性中枢神经系统恶性淋巴瘤(附10例病例报告)  

Primary central nervous system lymphoma:report of 10 cases

作　　者：陈喜林[1] 张伟京[1] 苏航[1] 仲凯励[1] 肖秀斌[1] 达永[1] 余金德[1] 何祥林[1] 俞受程[1] 

机构地区：[1]军事医学科学院附属医院,北京100039

出　　处：《军事医学科学院院刊》2003年第6期444-446,共3页Bulletin of the Academy of Military Medical Sciences

摘　　要：目的 :提高对原发性中枢神经系统恶性淋巴瘤 (PCNSL)临床特征的认识。方法 :回顾性分析经病理证实的10例PCNSL ,结合文献对其发病机制、临床表现和治疗方法等进行探讨。结果 :10例患者随访 3～ 4 8个月 ,中位时间 2 7.4个月。其中除手术外单纯放疗组、化疗加放疗组和干细胞移植治疗组的中位生存时间分别为 11.4 ,39.7和4 0个月。结论 :本病诊断难 ,病程短 ,预后差 ,加强以HD_MTX化疗为主的综合治疗是提高本病疗效的关键。Objective:To have a better understanding of the clinical characteristics of primary central nervous system lymphoma (PCNSL).Methods:The clinical data of 10 patients with PCNSL were studied retrospectively. The pathogenesis, clinical manifestation and treatment method were dicussed.Results:Ten patients were alive with a median follow-up of 27.4 months(ranged from 3 to 48 months). The median survival time was 11.4, 39.7 and 40 months for patients treated with RT, CHT→RT and BSCT.Conclusion:It is difficult to diagnose PCNSL, the patient′s survival time is short, and the prognosis of this disease is poor. Emphasizing combined treatment with HD-MTX-based chemotherapy is the crux of promoting the curative efficacy of this disease.

关 键 词：中枢神经系统肿瘤 恶性淋巴瘤 综合治疗 

分 类 号：R739.4[医药卫生—肿瘤]