^(12)C^(6+)离子辐照小鼠Lewis肿瘤的研究  

Study of Mouse Lewis Tumors by^(12)C^(6+) Ion Radiation

作　　者：李文建[1] 郭红云[2] 李德杏[2] 党秉荣[1] 马秋峰[1] 周利斌[1] 王潇[1] 郝冀芳[1] 毛淑红[1] 

机构地区：[1]中国科学院近代物理研究所,甘肃兰州730000 [2]甘肃省医学科学研究院,甘肃兰州730050

出　　处：《原子核物理评论》2003年第4期281-283,共3页Nuclear Physics Review

基　　金：中国科学院院长特别支持基金资助项目(TB990601)~~

摘　　要：研究了HIRFL提供的12C6+离子辐照C57BL/6J小鼠右后腿移植的Lewis肿瘤的生长延迟和碳离子辐照对Lewis肿瘤小鼠寿命的延长.结果表明,碳离子照射的小鼠肿瘤生长体积明显地小于对照的体积.在剂量相同、分次数辐照越多时,肿瘤生长就越缓慢,肿瘤抑制就越高.在辐照分次数相同时,不同剂量对受照肿瘤生长体积未产生差异.在4Gy×3,8Gy×3和12Gy×2组3种辐照剂量下,小鼠寿命的P值小于0.05;可知小鼠的寿命延长具有统计学意义.Growth delay of the transplantable Lewis tumors growing in right hind legs of C(57) BL/6J mice and life prolongation of the mice with Lewis tumors were investigated after()^(12)C^(6+) ion radiation at HIRFL. The results show that growth volumes of the mouse tumors following carbon radiation are distinctly less than control during 21 days; the more fractions of radiation with same doses, the slower growth of tumors and the higher inhibition of tumors; different doses with the same fractions of radiation does not induce difference for growth volume of the irradiated tumors; among 4 Gy×3, 8 Gy×3 and 12 Gy×2 groups P values of the mouse life are less than 0.05 and it indicates that their life prolongation has statistical significance.

关 键 词：碳离子 小鼠肿瘤 离子辐照 生长延迟 小鼠寿命 肿瘤抑制 肿瘤治疗 辐照剂量 

分 类 号：R730.55[医药卫生—肿瘤] Q691[医药卫生—临床医学]