OK-432对脐带血初始CD4^+T细胞向Th1细胞分化的诱导作用  

Effect of OK-432 on Inducing Differentiation from Naive CD4^+T Cells in Cord Blood to Th1 Cells

作　　者：台桂香[1] 刘静[2] 高素君[3] 

机构地区：[1]吉林大学基础医学院免疫学教研室,吉林长春130021 [2]长春市儿童医院内科 [3]吉林大学第一医院血液科

出　　处：《吉林大学学报（医学版）》2003年第6期751-752,779,共3页Journal of Jilin University：Medicine Edition

基　　金：教育部留学归国启动基金资助课题 (992 2 G1 6 7)

摘　　要：目的 :探讨链球菌 OK- 432 ( OK- 432 )的抗肿瘤机理。方法 :采用磁珠法分离脐带血初始CD4+ T细胞 ,经 OK- 432诱导培养后 ,应用酶联免疫吸附测定 ( ELISA)法测定培养细胞上清中细胞因子的水平。结果 :OK- 432刺激脐带初始 CD4+ T细胞分泌 IFN-γ的数量明显增加 ,而 IL- 4产生明显减少。结论 :OK- 432可诱导脐带血初始 CD4+ T细胞向Objective:To study the mechanism of OK 432 antitumor. Methods:Purified naive CD4 +T cells in cord blood were incubated by OK 432, then IFN γ and IL 4 from the supernatant of the cells cultured were determined by ELISA. Results:Naive CD4 +T cells in cord blood stimulated by OK 432 produced IFN γ and decreased IL 4. Conclusion:Naive CD4 +T cells in cord blood stimulated by OK 432 may differentiate to Th1.

关 键 词：溶血性链球菌制剂 佐剂 免疫 CD4阳性T淋G细胞 干扰素Ⅱ型 脐带血 抗肿瘤机理 细胞分化 

分 类 号：R730.5[医药卫生—肿瘤]