组蛋白去乙酰化酶1在人肺癌组织中的表达  

Expression of Histone Deacetylase 1 in Human Lung Cancer

作　　者：黄宏[1] 张珍祥[1] 徐永健[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院呼吸内科,武汉430030

出　　处：《华中科技大学学报（医学版）》2003年第6期622-624,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目 (No .3 9970 693 )

摘　　要：目的　探讨原发性肺癌组织中组蛋白去乙酰化酶 1(HDAC1)的表达及临床意义。方法　采用免疫组织化学法和原位杂交法 ,分别测定 2 8例肺癌组织及其癌旁肺组织中HDAC1表达。结果　在 2 8例肺癌组织中HDAC1的蛋白质和mRNA的A值分别为 0 2 1± 0 0 2 ,0 18± 0 0 3 ,而其癌旁肺组织中HDAC1的蛋白质和mRNA的A值分别为 0 16± 0 0 2 ,0 11± 0 0 1,两者相比差异均有显著性意义 ,P <0 0 5。Objective To investigate the expression of histone deacetylase 1 (HDAC1) in lung cancer tissue. Methods The expression of HDAC1 protein and mRNA in 28 cases of surgically resected lung cancer tissues were detected by immunohistochemical a nd in situ hybridization assays. Results The A value of HDAC1 protein and mRNA in lung cancer ti ssue was 0 21±0 02 and 0 18±0 03 respectively, but that in the tissue adja cent to lung cancer was 0 16±0 02 and 0 11±0 01 respectively, with differe nce being significant between them (P<0 05). Conclusion There is overexpression of HDAC1 in lung cancer tiss ue.

关 键 词：组蛋白去乙酰化酶1 肺癌 表达 免疫组织化学 原位杂交 癌组织 

分 类 号：R734.2[医药卫生—肿瘤]