转化生长因子β_1在食管鳞癌中表达的临床研究  

Clinical Study of Transforming Growth Factor B_1 Expression in Esophageal Squamous Carcinoma

作　　者：范虹[1] 曾亮[1] 王群[1] 

机构地区：[1]复旦大学附属中山医院胸外科,200032

出　　处：《胃肠病学》2003年第6期349-352,共4页Chinese Journal of Gastroenterology

摘　　要：背景:转化生长因子(TGF)-β1在多种肿瘤的发生、发展和凋亡过程中发挥重要作用,但其在食管癌中的作用及其与肿瘤血管生成的关系尚未明确。目的:研究TGF-β1在食管癌中的表达及其与肿瘤血管生成的关系。方法:采用免疫组化方法检测45例食管鳞癌组织和10例正常食管组织中TGF-β1的表达和肿瘤微血管密度(MVD)。应用SPSS 10.0统计软件分析TGF-β1的表达与食管癌临床病理参数、预后和肿瘤MVD的关系。结果:正常食管组织黏膜细胞未见异常染色;食管癌患者的TGF-β1表达阳性率为77.8％(35/45),肿瘤MVD平均值为15.58。TGF-β1的表达与食管癌临床病理参数和预后无关,但与肿瘤MVD显著相关(r=0.428,P=0.003)。结论:TGF-β1的表达与食管鳞癌的发生有关,但与其进展无关。TGF-β1在食管鳞癌的血管生成中可能具有一定作用。Background: Transforming growth factor (TGF)-β1 plays an important role in tumorigenesis, progression and apoptosis in many kinds of tumors, but its role in esophageal carcinoma and the correlation between TGF-β1 and tumor angiogenesis is as yet unclarified. Aims: To investigate the expression of TGF-β1 in esophageal carcinoma and its relation to tumor angiogenesis. Methods: Immunohisto-chemistry method was used to detect the expression of TGF-β1 and intratumoral microvessel density (MVD) in 45 cases of esophageal squamous carcinomatous tissues and 10 normal esophageal tissues. The relationship between TGF-β1 expression and clinicopathological parameters, prognosis and intratumoral MVD in esophageal carcinoma was analyzed by SPSS 10.0 statistic software. Results: No abnormality was seen in the mucosal cells of normal esophageal tissues. TGF-β1 expression was identified in 77.8% (35/45) of patients with esophageal carcinoma, and the mean value of intratumoral MVD was 15.58. The expression of TGF-β1 was not associated with any of the clinicopathological parameters as well as the prognosis of esophageal carcinoma. A significant correlation was noted between TGF-β1 expression and intratumoral MVD (r = 0.428, P= 0.003). Conclusions: The expression of TGF-β1 is associated with tumorigenesis, but not the tumor progression in esophageal squamous carcinoma. TGF-β1 may be one of the factors in the angiogenesis of esophageal squamous carcinoma.

关 键 词：食管鳞癌 食管肿瘤 转化生长因子Β1 血管生成 微血管密度 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]