己酮可可碱对小鼠急性脑缺血的保护作用研究  

Study of Protective Effect of Pentoxifylline (PTX)on Acute Cerebral Ischemia in Mice

作　　者：李晓宇[1] 涂长春[1] 邱常青[1] 胡锦芳[2] 王劲柏[2] 

机构地区：[1]江西医学院药理学教研室,江西南昌330006 [2]江西医学院第一附属医院药剂科,江西南昌330006

出　　处：《江西医学院学报》2003年第6期37-39,共3页Acta Academiae Medicinae Jiangxi

摘　　要：目的　研究己酮可可碱 (PentoxifyllinePTX)对急性脑缺血所致小鼠大脑功能改变的保护作用。 方法　采用双侧颈总动脉不完全和完全结扎法及小鼠快速断头法 ,观察小鼠在急性脑缺血时的所产生的神经症状、存活时间和脑细胞的改变及己酮可可碱 (PTX)的保护作用。结果　 2 5、5 0mg·kg -1的PTX可以显著减少急性不完全性脑缺血致小鼠神经症状的发生 ,减少小鼠大脑细胞的坏死百分率 ;可以显著延长急性完全性脑缺血小鼠断头张口喘气时间并能增加小鼠耐缺氧的存活时间。结论　PTX对小鼠急性完全和不完全性脑缺血具有保护作用。Objective To study the effect of pentoxifylline(PTX)on brain function in acute cerebral ischemia mice.Methods Cerebral ischemia was induced by cutting head and ligating bilateral carotid arteries completely or incompletely.The nerve symptom,survival time and the change of brain cell in mice were observed during the acute cerebral ischemia and the protective effect of PTX on acute cerebral ischemia mice was evaluated.Results The stroke index score and the percentage of denaturation or necrosis of brain cell in the ischemic mice were obviously reduced by PTX at dose of 25 and 50 mg·kg -1 .The persistent time of gasping of mice by decapitation and survival time of mice by bilateral carotid arteries ligation were obviously prolonged by the same dose of PTX.Conclusion PTX has a protective effect on acute cerebral ischemia mice.

关 键 词：己酮可可碱 脑缺血 小鼠 保护作用 

分 类 号：R-332[医药卫生]