幽门螺杆菌与一氧化氮及胃粘膜病理变化的关系  

The Relationship of Helicobacter Pylori and the Level of Nitric Oxide with Gastric Mucosa Pathological Development

作　　者：王永福[1] 耿立霞[1] 王素青[1] 陈鹏[1] 杨国安[1] 王宏坤[1] 

机构地区：[1]内蒙古包头医学院第一附属医院,包头014010

出　　处：《中国误诊学杂志》2003年第12期1781-1783,共3页Chinese Journal of Misdiagnostics

基　　金：包头市医药卫生基金资助项目;资助编号 :2 0 0 0 - 2 6

摘　　要：目的 :通过观察 Hp感染后血清 NO及 NOS水平变化及其对胃粘膜病理改变的影响 ,来探讨 Hp的可能致病机理。方法 :随机选取 Hp阳性患者 5 0例 ,Hp阴性患者 35例 ,病理学检查的同时检测其血清中 NO及 NOS的含量。结果 :Hp阳性组血清 NO和 NOS含量分别高于 Hp阴性组 (P<0 .0 1)。在 Hp阳性患者中 ,血清中 NO和 NOS含量在慢性炎症组明显低于其他 3组 (P<0 .0 5 )。但在 Hp阴性组中 ,慢性胃炎患者血清中 NO含量低于其他 3组 (P<0 .0 5 ) ,而血清中 NOS含量在各组之间无明显差异。结论 :Hp诱导的 NO表达水平可能与胃癌前期病变相关。除 Hp可导致 NO合成增加外 ,癌前期病变还可通过其他炎症介质激活 NO的产生途径。Objective:To observe the effect of the level of nitric oxide in Helicobacter pylori infection patients, and the relationship of gastric mucosa Pathological development with them.Methods:50 cases with Hp infection were treated as positive group and 35 cases with Hp negative as control group. The serum level of nitric oxide (NO) and NOS were detected.Results:The level of NO and NOS in positive group were higher than them in negative group (P<0.01).The level of NO and NOS in active gastritis were apparently lower than pre-neoplasm diseases(P<0.05), such as atrophy, intestinal metaplasia and heterogenesis.Conclusion:Infection of Helicobacter pylori can induce elevation of nitric oxide synthesis(NOS), which produced NO, It is correlation with pathological development of gastric mucosa in chronic gastric diseases.

关 键 词：螺杆菌 幽门 一氧化氮 一氧化氮合酶 胃粘膜病理 

分 类 号：R570.2[医药卫生—消化系统]