雷珠单抗联合激光治疗视网膜分支静脉阻塞所致黄斑水肿临床疗效分析  

Clinical analysis of treatment of macular edema caused by retinal branch vein occlusion with ranibizumab combined with laser

作　　者：段娜[1] 陈梦平[2] DUAN Na;CHEN Meng-ping(Department of Ophthalmology,The Third People Hospital of Huizhou,Huizhou 516002,China;Department of Ophthalmology,the Second People Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]惠州市第三人民医院眼科,广东惠州516002 [2]郑州市第二人民医院眼科,河南郑州450015

出　　处：《延安大学学报（医学科学版）》2019年第1期47-50,共4页Journal of Yan'an University:Medical Science Edition

摘　　要：目的探讨分析雷珠单抗联合激光治疗视网膜分支静脉阻塞所致黄斑水肿的临床疗效。方法选取2015年7月至2018年1月惠州市第三人民医院眼科收治的84例视网膜分支静脉阻塞所致黄斑水肿患者随机分为观察组和对照组,对照组仅给予激光治疗,观察组给予雷珠单抗联合激光治疗,比较两组患者临床疗效,治疗前、治疗后6个月log MAR BCVA、CMT值,并发症发生情况。结果观察组患者临床疗效总有效率为95. 24%,较对照组显著提高,差异具有统计学意义(P <0. 05),治疗前两组log MAR BCVA、CMT值差异无统计学意义(P> 0. 05),治疗后6个月两组患者log MAR BCVA、CMT值均显著下降,且治疗后6个月观察组患者log MAR BCVA、CMT值下降更显著,差异具有统计学意义(P <0. 05),观察组并发症发生显著低于对照组,差异具有统计学意义(P <0. 05)。结论雷珠单抗联合激光治疗视网膜分支静脉阻塞所致黄斑水肿疗效显著,减小黄斑中心凹厚度,促进患者视力恢复,值得推广。Objective To investigate the clinical efficacy of ranibizumab combined with laser in the treatment of macular edema caused by branch retinal vein occlusion. Methods From July 2015 to January 2018,84 patients with macular edema caused by branch retinal vein occlusion were randomly divided into observation group and control group. The control group was given only laser treatment,and the observation group was given ranibizumab combined with laser treatment. Results The total effective rate of clinical observation in the observation group was 95. 24%,which was significantly higher than that of the control group,and the difference was statistically significant( P <0. 05). There was no significant difference in logMAR BCVA and CMT between the two groups before treatment( P> 0. 05). The logMAR BCVA and CMT values of the two groups were significantly decreased at 6 months after treatment,and the logMAR BCVA and CMT values were significantly lower in the observation group at 6 months after treatment. The difference was statistically significant( P < 0. 05). The incidence was significantly lower than that of the control group,and the difference was statistically significant( P < 0. 05). Conclusion The effect of ranibizumab combined with laser on macular edema caused by branch retinal vein occlusion is significant,reducing the thickness of foveal fovea and promoting vision recovery. It is worthy of promotion.

关 键 词：雷珠单抗 激光治疗 视网膜分支静脉阻塞 黄斑水肿 

分 类 号：R779.63[医药卫生—眼科]