硒代二半胱氨酸对白血病细胞系的诱导分化研究  

Differentiation in Cultured Leukemic Cells Treated with Dicysteine Selenium

作　　者：张俊德[1] 郑景熙[1] 龚颜德[1] 邹恒琴[1] 古维新[1] 

机构地区：[1]第一军医大学珠江医院,第一军医大学防原教研室

出　　处：《广东微量元素科学》1995年第3期10-12,共3页Trace Elements Science

摘　　要：硒抑制体外白血病细胞的生长和增殖，并能诱导部分白血病细胞分化成熟，但其药理作用因硒制剂的不同而异．硒代二半胱氨酸抑制Ｖ９３７和Ｋ５６２白血病细胞的生长和增殖，半数抑制浓度为３．０μｍｏｌ／Ｌ．经３．０μｍｏｌ／Ｌ硒代二半胱氨酸作用３天后，Ｕ９３７，细胞吞噬率以５％上升至１４％，Ｋ５６２细胞内血红蛋白含量由０．２０增至０．４０μｇ／１０６细胞，说明硒代二半胱氨酸能诱导部分白血病细胞分化成熟．The selenium compound-dicysteine selenium has been shown to inhibit the growth of U937 and K562 leukemic cells with IC50 of 3. oμmol/L. Furthermore.the differentiation-inducing effects were observed. After incubation for 3 days with dicysteine selenium at concentration of 3. oμmol/L. morphological and functional differentiation has occurred in some of the leukemic cells. 14% U937 cells were capable of phagocytosis after treated with dicysteine selenium while only 5% U937 cells were capable of phagocytosis in controls.Meanwhile dicysteine selenium was effective in stimulating hemoglobin synthesis in K562 cells because more hemoglobin product was determined in drug-treated cells(0. 4μg/106 cells) than in controls (0.2μg/106 cells).

关 键 词：硒代二半胱氨酸 白血病 细胞增殖 诱导分化 硒制剂 血红蛋白 

分 类 号：Q581[生物学—生物化学] R733.7[医药卫生—肿瘤]