X-刀治疗大鼠胶质瘤的磁共振灌注成像  

MR perfusion weighted imaging of rat′s glioma treated with stereotactic radiosurgery

作　　者：钱银锋[1] 陈骏[1] 余永强[1] 张诚[1] 

机构地区：[1]安徽医科大学第一附属医院放射科,合肥230022

出　　处：《放射学实践》2003年第12期902-904,共3页Radiologic Practice

基　　金：安徽省自然科学基金资助课题 (990 4 4 530 )

摘　　要：目的 :观察X 刀对大鼠脑胶质瘤的治疗作用 ,探讨MR灌注成像 (PWI)对X 刀治疗疗效的早期评价。方法 :2 0只SD雄性大鼠右尾状核接种C6胶质瘤细胞复制大鼠脑胶质瘤模型。治疗组 10只接种胶质瘤细胞后第 15天行X 刀治疗 ,10只对照组未行治疗 ,分别第 15天 (治疗组X 刀治疗前 )和第 17天行PWI ,计算肿瘤的相对局部脑血容量(rrCBV) ,观察治疗后肿瘤rrCBV的变化率 ,并与荷瘤鼠存活期进行回归分析。结果 :肿瘤接种成功率为 10 0 %。治疗组治疗后 48h肿瘤的rrCBV明显减小 ,其下降百分比平均为 3 5 .8%。对照组和治疗组大鼠生存期分别为 2 2 .8和 3 0 .5d ,两组间差异有显著意义。X 刀治疗后肿瘤rrCBV的下降百分比与大鼠生存期密切相关 (r =0 .82 ,P <0 .0 5 )。结论 :X 刀治疗能延长荷胶质瘤大鼠生存期 。Objective:To observe the therapeutical effect of stereotactic radiosurgery in glioma of rat,to study the value of MR perfusion weighted imaging (PWI) in predicting the response of the tumor to stereotactic radiosurgery therapy at early time.Methods:C 6 glioma cells were implanted into 20 SD rats intracranially.The rats were divided into 2 groups with 10 in treatment group and controll group each.At the 15th day after tumor implantation,the rats in treatment group were performed stereotactic radiosurgery therapy with 25Gy.PWI was performed to measure the relative regional cerebral blood volume (rrCBV) of the tumor at the 15 (before therapy at treatment group) and 17 day after tumor implantation.The relation between the change of rrCBV and the survival time was compared by regression analysis.Results:All tumor implantation was successful in all rats.The average survival time of non treated group was 22.8 days,but the treated group was 30.5 days,there was statistically significant difference between two groups.The rrCBV of tumor declined 48h after stereotactic radiosurgery treatment,the rate of declination was 35.8%,which was significantly correlated with the survival time (r=0.82, P<0.05).Conclusion:Stereotactic radiosurgery therapy can prolong the survival time of rat with brain glioma,which can be evaluated by PWI at relatively early stage.

关 键 词：X-刀 治疗 大鼠 胶质瘤 磁共振灌注成像 

分 类 号：R730.4[医药卫生—肿瘤]