连续二次大剂量化疗联合活化的造血干细胞和免疫细胞移植治疗难治性非小细胞肺癌  

Double-Cycle high Dose Chemotherapy with Autologous Hematopoietic Stem Cells and Immunocytes Transplantation in Refractory Non Small Cell Lung Cancer

作　　者：陈国强[1] 郭坤元[1] 汪森明[1] 赵燕[1] 沈淑华[1] 王薇[1] 顾佩霞[1] 王兵[1] 

机构地区：[1]第一军医大学珠江医院肿瘤科,广洲510282

出　　处：《中国肿瘤生物治疗杂志》1996年第1期45-47,54,共4页Chinese Journal of Cancer Biotherapy

摘　　要：选择8例经常规剂量化疗未能完全缓解的难治性非小细胞肺癌患者为观察对象,采用在4个月内完成连续两次大剂量化疗联合自体骨髓、外周造血干细胞和免疫细胞移植的方案进行治疗。化疗方案为CTX 3000mg/m^2、ADM 90mg/m^2、DDP150mg/m^2、VP16 900mg/m^2,分量于3天静滴。结果显示,所有患者的造血功能均在移植后25天内重建,大多数患者的免疫功能较快重建。经两个疗程治疗后,CR3例,PR3例、NC1例死亡1例。本研究表明,大剂量化疗可提高难治性非小细胞肺癌的疗效,对带瘤患者有必要行二次移植治疗,此方案是安全的。We treated 8 patients with refractory non small cell lung cancer by the method of double - cycle high dose chemotherapy with actwated autologous bone marrow, peripheral stem cell, and immunocytes trnsplantation which takes four months. Regimen consist of cyclophospamide 3600mg/m2, adriamycin 90mg/m2 , cisplatin 150mg/m2, and etoposide 900mg/m2 given in three days. The results showed that all the treated patients hematopoietic function recovered in twenty five days after transplantation and some of the patients' immune function recovered more quickly. 3 patients were abtained complete responses , 3 patients partial responses, and 1 patient no change 1 patient died after the double cycle treatment. This research suggests that usage of high dose chemotherapy can improve the treating effect of refractory non small cell lung cancer. It is necessary for the patient with disease to use the double cycle transplantation treatment. The treatment is safe.

关 键 词：大剂量 化疗 造血干细胞 免疫细胞移植 治疗 难治性非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]