乳腺专用PET临床初步应用  

The preliminary clinical application of MAMMI dedicated breast PET

作　　者：鲍晓[1,2,3,4,5] 胡四龙[1,2,3,4,5] 程竞仪 杨忠毅[1,2,3,4,5] 刘帅[1,2,3,4,5] 刘芮 孙艺斐[1,2,3,4,5] 王思阳 刘畅[1,2,3,4,5] 姚之丰 张勇平 章英剑 

机构地区：[1]复旦大学附属肿瘤医院核医学科 [2]复旦大学上海医学院肿瘤学系,上海200032 [3]上海市质子重离子医院核医学科,上海201321 [4]复旦大学生物医学影像研究中心,上海200032 [5]上海分子影像探针工程技术研究中心(筹),上海200032

出　　处：《肿瘤影像学》2015年第3期179-184,共6页Oncoradiology

摘　　要：目的:探讨乳腺专用PET的临床应用价值。方法:选取76例于本院行18F-FDG PET/CT检查发现乳腺病灶,或临床疑有隐匿性乳腺癌行18F-FDG PET/CT检查的患者,在知情同意下进行乳腺专用PET复查,测定最大标准摄取值(SUVmax)。采用独立样本t检验比较不同病灶大小、超声分级、分子亚型之间SUVmax的差异。结果:最终获得病理并纳入分析48例,专用PET检出病灶63个,最小病灶约0.3 cm。恶性病灶长径<1 cm、1~2 cm和>2 cm时,SUVmax平均值分别为4.58±2.01、7.51±3.10和11.27±5.29,两两比较差异均有统计学意义(P<0.01或P<0.05);乳腺影像报告和数据系统(BI-RADS)4级与5级之间SUVmax差异也有统计学意义(P<0.05);各分子亚型之间SUVmax差异无统计学意义。结论:乳腺专用PET对探测乳腺小病灶、多中心、多原发病灶具有很好的临床应用价值。Objective: To evaluate the preliminary clinical application value of MAMMI dedicated breast PET. Methods: A total of 76 patients with positive breast lesions on whole-body 18F-fluorodeoxyglucose(18F-FDG) PET/CT or suspicious occult breast cancer voluntarily underwent MAMMI PET in prone position after whole-body 18F-FDG PET/CT. The maximal standardized uptake values(SUVmax) were compared according to lesion size, ultrasound grading and molecular subtype of breast cancer. Results: MAMMI PET visualized 63 lesions in 48 patients with specific pathologic diagnosis. The smallest lesion was 0.3 cm indiameter. Malignant lesions were classified into 3 groups based on diameter as follows: grade 1, 1 cm or smaller; grade 2, 1 to 2 cm; and grad 3, larger than 2 cm. The mean values of SUVmax of them were 4.58 ±2.01, 7.51 ±3.10 and 11.27±5.29, respectively, and there were significant differences in SUVmax through pairwise comparison(P<0.01 or P<0.05). Difference in SUVmax was also observed between Breast Imaging Reporting and Data System(BI-RADS) grade 4 and grade 5(P<0.05). But there were no significant differences among different molecular subtypes. Conclusion: MAMMI PET has a promising clinical value in detecting small, multicenter and multiple primary breast lesions.

关 键 词：乳腺专用PET 乳腺癌 18F-脱氧葡萄糖 

分 类 号：R737.9[医药卫生—肿瘤] R730.44[医药卫生—临床医学]