基于^(11)C-蛋氨酸PET显像的肿瘤代谢体积参数在脑胶质瘤诊断中的应用价值研究  

Diagnostic value of volume-based parameters by ^(11)C-methionine PET imaging in glioma patients

作　　者：黄喆慜[1] 葛璟洁[1] 张慧玮[1] 任树华[1] 管一晖[1] 

机构地区：[1]复旦大学附属华山医院PET中心,上海200235

出　　处：《肿瘤影像学》2016年第3期252-256,278,共6页Oncoradiology

基　　金：国家自然科学基金(No:81271516;81571345);上海市科委项目(No:13JC1401503;14DZ1930402);复旦大学老年医学专项支持计划青年学者创新研究项目(No:IDF151006)

摘　　要：目的:初步探索基于体积参数的蛋氨酸(methionine,MET)PET显像在胶质瘤诊断中的应用价值。方法:回顾性分析经术后病理证实的36例胶质瘤患者的MET PET图像并以此图像数据为基础计算相应的体积参数。结果:基于MET PET图像的体积参数在不同世界卫生组织(World Health Organization,WHO)分级的胶质瘤之间存在显著差异,但当包括少突胶质细胞瘤时,WHOⅡ级与Ⅲ级胶质瘤之间体积参数差异不显著。结论:基于MET PET的代谢体积参数对胶质瘤诊断具有较好的应用价值,但实际应用时应注意考虑少突胶质细胞瘤等特殊摄取情况。Objective: To explore the diagnostic value of volume-based parameters by ^(11)C-methionine(MET) PET imaging in glioma patients. Methods: A total of 36 patients who underwent surgical treatment and were confirmed of glioma were retrospectively analyzed. The volume-based parameters were calculated based on MET PET images. Results: The volumebased parameters showed significant differences among different grades of gliomas. When oligodendroglioma was considered, the difference between grade II and III was not significant. Conclusion: The volume-based parameters by MET PET are valuable in the diagnosis of glioma. The clinical application should be paid attention when certain type of tumor such as oligodendroglioma is considered.

关 键 词：蛋氨酸 正电子发射断层成像 胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤] R730.44[医药卫生—临床医学]