叠氮化钠的毒性研究  

Studies on toxicity of sodium azide

作　　者：吕伯钦[1] 曾昭慧[1] 邓海[1] 庞应发[1] 毕文芳[1] 王志爽[1] 孟慧林[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所,北京100050

出　　处：《卫生研究》1992年第5期228-231,共4页Journal of Hygiene Research

摘　　要：研究了叠氮化钠的急性和亚慢性毒性,结果表明,叠氮化钠是一种剧毒物质,可抑制过氧化氢酶,但恢复较快。亚慢性中毒的主要表现为后肢瘫痪,血压下降及体重减轻等。明显毒性作用剂量为10～15mg/kg,中等剂量(5mg/kg)可见血压下降、肝脏增大,而无害作用剂量为2mg/kg。过氧化氢酶的抑制可能是中毒的主要毒性作用之一。The toxic effect, acute and subchronic toxicity of sodium azide in rats were carried out. It indicated that this agent may inhibit the serum and liver peroxidase, of which the decreased activity was soon returned to normal level. In subchronic experiment, Paralysis of hind limbs, decreased blood presure and the loss of body weight were major toxic manifestation in administrated rats. The marked toxic effect dose of sodium azide was 10～15mg/kg bw and no adverse effect dose was 2mg/kg bw The inhibition of peroxidase activity was probably one of the major toxic effects of sodium azide.

关 键 词：叠氮化物 毒性 毒作用 

分 类 号：R992[医药卫生—毒理学]