复方斑鳌注射液联合化疗治疗老年晚期胃癌的疗效分析  

Analysis of Banmao compound combined with chemotherapy in treating elderly patients with late stage gastric cancer

作　　者：丁祥林 

机构地区：[1]江苏省苏州永鼎医院肿瘤科,江苏苏州215200

出　　处：《慢性病学杂志》2015年第6期630-631,636,共3页Chronic Pathematology Journal

摘　　要：目的探讨复方斑鳌注射液联合化疗治疗老年晚期胃癌患者的疗效。方法老年晚期胃癌患者共60例,随机分为观察组及对照组,每组30例,两组患者给予相同的化疗方案,观察组在此基础上加用复方斑蝥注射液(100 ml/次,静脉注射,第1~10天)。接受2个周期治疗后,评价患者的疗效,采用KPS评分评价患者的生活质量,并比较两组的不良发应发生率。结果观察组与对照组患者均顺利完成2个周期的化疗,且效果可评价。观察组实体瘤完全缓解(CR)、实体瘤部分缓解(PR)、实体瘤未发生明显变化(SD)、实体瘤进一步发展(PD)分别为0、16、9、5例,有效率(RR)53.33%;对照组分别为0、10、12、8例,RR 33.33%,两组差异有统计学意义(χ~2=13.071,P<0.05)。观察组中生活质量改善者(KPS评分≥80分)5例(16.67%),稳定者16例(53.33%),对照组分别为2(6.67%)、7例(23.33%),两组生活质量改善率和稳定率差异均有统计学意义(χ~2值分别为6.184、16.071,P均<0.05)。观察组患者中不良反应的发生率(56.67%)低于对照组(90.00%),差异有统计学意义(χ~2=17.451,P<0.05)。结论复方斑蝥注射液联合化疗治疗老年晚期胃癌可显著提高短期治疗效果,减少及减轻化疗过程中的不良反应,显著改善患者生活质量。Objective To evaluate the effect of Banmao compound combined with chemotherapy in treating elderly patients with late stage gastric cancer.Methods A total of 60 elderly patients with late stage gastric cancer in the Department of Oncology of Suzhou Yongding Hospital were randomly and equally divided into the treatment and the control group.Both groups underwent the same chemotherapy,while the treatment group was given the additional Banmao compound injection.After 2 treatment cycle,the difference between the two groups were evaluated by comparing the Karnofsky Performance Status(KPS) score,an index of the patients' quality of life(QOL),and by comparing the proportion of adverse reactions.Results Both groups underwent 2 treatment cycles with effects evaluated.There was 0 case of complete response(CR),16 cases of partial response(PR),9 cases of stable disease(SD) and 5 cases of progressive disease(PD)in the treatment group,in contrast to 0 case of CR,10 cases of PR,12 cases of SD and 8 cases of PD in the control group.The response rate(RR,the sum of CR and PR) was 53.33%in the treatment group,and 33.33%in the control group,with the difference statistically significant(χ~2=13.071,P<0.05).There were 5 cases of QOL improvement(16.67%)and 16 cases of QOL stability(53.33%) in the treatment group,in contrast to 2 cases of QOL improvement(6.67%),7 cases of QOL stability(23.33%) in the control group.The proportions of patients with QOL improvement and stability in the treatment group were higher than those in control group(χ~2=6.184,16.071,respectively,both P<0.05).The incidence of adverse reaction in the treatment group was lower than that in control group(56.67%vs.90.00%,χ~2=17.451,P<0.05).Conclusions The effect of chemotherapy for elderly patients with late stage gastric cancer is enhanced by injection of Banmao compound,whereas the adverse reaction of chemotherapy is decreased and QOL improved.Banmao compound injection is worthy of further exploration.

关 键 词：胃肿瘤 复方斑蝥注射液 化学疗法 老年 

分 类 号：R735.2[医药卫生—肿瘤]