不同剂型非诺贝特对高血脂大鼠血脂水平的影响  

The effects of different fenofibrate preparation on the hyperlipidaemic rats

作　　者：王倩[1] 包存刚 余以兵 郭绪义 汪海[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]徐州恩华赛德药业有限责任公司,徐州221007 [3]北京赛德维康医药研究院,北京100039

出　　处：《中国药理学通报》2003年第7期833-836,共4页Chinese Pharmacological Bulletin

摘　　要：目的　比较微粉化非诺贝特与标准化非诺贝特的降血脂作用。方法　用高脂饲料喂养Wistar大鼠 ,导致大鼠高脂血症 ,然后分别给予微粉化非诺贝特每天 2 0、30、40mg·kg- 1 及标准化非诺贝特每天 2 0、30、40、60、80mg·kg- 1 。于实验d 1 0取血清测定TC、TG。结果　①相同实验条件下 ,微粉化非诺贝特胶囊降低高血脂大鼠血清TC和TG的最低有效剂量为每天 30mg·kg- 1 ,而标准化非诺贝特胶囊为每天 80mg·kg- 1 ;②两种剂型非诺贝特在有效剂量下 ,可使高血脂大鼠的TG水平降至正常 ,使高血脂大鼠的TC水平下降 36 69%～ 51 56 %。结论　微粉化非诺贝特优于标准化非诺贝特制剂 ,非诺贝特对血脂的调节以降低血清TG为主 。AIM To compare the effects of micronised fenofibrate with those of standard fenofibrate on regulating serum lipid. METHODS Wistar rats were fed by the hyperlipids food to induce hypolipidemia, and then orally treated with 20,30,40 mg·kg -1 per day micronised fenofibrate and 20,30,40,60,80 mg·kg -1 per day standard fenofibrate for 10 days. At the tenth day, serum total cholesterol and triglycerides were measured. RESULTS 1 In the same experimental conditions,the minimal efficacious dose of the micronised fenofibrate is 30 mg·kg -1 , but that of the standard fenofibrate is 80 mg·kg -1 ; 2 Using efficacious doses, both kinds of fenofibrate could decrease the content of triglyceride to normal level. They also could decrease the level of total cholesterol by 36 69%～51 56%. CONCLUSION The effects of micronised fenofibrate are better than those of standard fenofibrate, which mainly decreases the level of triglyceride. Micronised fenofibrate also decreases level of serum total cholesterol.

关 键 词：微粉化非诺贝特 标准化非诺贝特 高血脂大鼠 甘油三酯 总胆固醇 

分 类 号：R-332[医药卫生] R344.81