事件相关电位与视觉诱发电位诊断帕金森病的价值  

The change of event-related evoked potentials and visual evoked potentials in patients with Parkinson disease

作　　者：郭斌[1] 郭丽华[1] 陈静[1] 陈瑞冬[1] 李伟[1] 

机构地区：[1]山东大学齐鲁医院,山东济南250012

出　　处：《山东医药》2004年第1期6-8,共3页Shandong Medical Journal

摘　　要：目的　探讨事件相关电位 (ERPs)和视觉诱发电位 (VEP)在帕金森病中 (PD)的诊断作用。方法　对 6 0例正常对照组和 5 8例无认知障碍的 PD患者组进行了 ERPs和 VEP检测。结果　 PD组 ERPs的 P30 0 波潜伏期较对照组的明显延长 (P<0 .0 5 ) ,波幅则较对照组明显降低 (P<0 .0 5 ) ;PD组 VEP的 P1 0 0 波潜伏期较对照组明显延长 (P<0 .0 5 ) ,而波幅则无显著性差异 (P>0 .0 5 )。结论　 ERPs的 P30 0 和Objective To investigate the changes of event-related potentials(ERPs)and visual evoked potentials in patients with Parkinson disease(PD).Methods ERPs and VEP were studied in 58 patients with PD(PD group)and 60 controlers(control group).Results The latency and amplitude of P 300 in PD significantly prolonged and reduced,both P<0.05,compared with the control group.The latency of P 100(VEP)was prolonged significantly but the amplitude was not reduced significantly,compared with the control group.Conclusion P 300 has specific value in detecting the subclinical cognitive impairment and P 100 is able to detect the function of visual conduction pathway.

关 键 词：事件相关电位 视觉诱发电位 诊断 帕金森病 认知功能障碍 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R741.044[医药卫生—临床医学]