愈痫灵颗粒剂水提醇沉工艺中浓缩、纯化及干燥条件的研究  

Concentration, purification and drying of Yuxianling Granules under aqueous extr action alcohol precipitation

作　　者：何群[1] 王净净[1] 赵碧清[1] 姚光辉[1] 刘亮[1] 

机构地区：[1]湖南中医学院,湖南长沙410004

出　　处：《中成药》2004年第1期12-15,共4页Chinese Traditional Patent Medicine

基　　金：湖南省卫生厅中医药管理局资助项目 ( 2 0 2 2 8)

摘　　要：目的 :为探讨愈痫灵颗粒剂浓缩、纯化及干燥的最合理工艺条件 ,缩小服用剂量 ,保证药效 ,为工业化生产提供依据。方法 :以阿魏酸及浸膏得率为评价指标 ,采用正交设计实验及对比实验优选本制剂水提醇沉工艺中浓缩、纯化及干燥过程的最佳操作条件。结果 :药材水提液浓缩至 0 .5∶1(即原药材量∶浓缩体积 (毫升 ) ) ;醇沉时药液含醇量达 60 % ;在60℃以下浓缩、回收乙醇及进行干燥。结论AIM: To specify optimization of the concentration, purification and drying for prepar ati on of Yuxianling Grannles and decrease the dosage on condition that is retentive of potency in order to provide a basis for mass production. METHODS: The contents of ferulic acid and the amount of extract wer e used as marker, the optimium of concentration, purification and drying for pr eparation were selected by orthogonal design and contrast test during aqueous ex tract alcohol precipitation process. RESULTS: Condition was optimum of herb-to-extract ratio in the range of 0.5 ∶1, pr ecipitation with ethanol containing 40% water and drying temperature not to exce ed 60℃ . CONCLUSION: The highest yield of active priciples is obtained by c ondition above.

关 键 词：愈痫灵颗粒剂 水提醇沉 阿魏酸 浓缩 纯化 干燥 

分 类 号：R284.2[医药卫生—中药学]