食管癌切除患者胸导管预防性结扎的细胞免疫及临床研究  

Cellular Immunity and Clinical Research on the Patients with Esophageal Carcinoma Underwent Resection and Preventive Thoracic Duct Ligation

作　　者：王忠民[1] 乔刚[1] 李汉臣[1] 

机构地区：[1]新乡医学院第一附属医院胸心外科,河南卫辉453100

出　　处：《中国医师杂志》2003年第11期1506-1507,共2页Journal of Chinese Physician

摘　　要：目的　探讨食管癌切除患者术中预防性结扎胸导管的免疫学依据。方法　 5 66例 0～Ⅲ期的食管癌切除患者术中预防性结扎了胸导管 ,随访 3月～ 1年 (随访率 73 8%)。随即抽取 74例患者 ,以同期随即抽取 3 4例未结扎患者作为对照 ,术后 3周内抽取外周血用碱性磷酸酶抗碱性磷酸酶 (APAAP)法进行检测CD3 + 、CD4+ 、CD8+ 、CD+ 1 6+ 56T淋巴细胞。结果　胸导管结扎组与未结扎组术后各期CD3 + 、CD4+ 、CD8+ 、CD+ 1 6+ 56T淋巴细胞均无显著性差异 (P >0 0 5 ) ;随访病例未发现淋巴淤积及水肿现象。结论　胸导管结扎是预防食管癌术后乳糜胸发生的有效方法 ,并不会影响患者的细胞免疫 。Objective To explore the immunological change on preventive thoracic duct ligation in the patients with esophageal carcinoma underwent resection. Methods 566 patients with esophageal carcinoma underwent resection and thoracic duct ligation were followed up 3 monthes ～ 1 year, and the follow-up rate was 73 8%. 74 cases of patients were randomly selected from the 566 patients as experimental group, and 34 cases of patients without thoracic duct ligation were selected as control group. The number of CD 3 +,CD 4 +,CD 8 + and CD + 16+56 T lymphocytes in the two groups was determinded by APAAP method 3 weeks after postoperation. Results The number of CD 3 +、CD 4 +、CD 8 +、CD + 16+56 T lymphocytes in both groups had not significant difference during each period of postoperation(P>0 05). Lymphatic deposit and edema were not observed in follow-up cases. Conclusions Thoracic duct ligation could prevent the patients with esophageal carcinoma underwent resection from postoperative chylothorax. It can neither damage the cellular immunity nor lymphatic circulation.

关 键 词：胸导管 食管癌 细胞免疫 淋巴回流 

分 类 号：R735.1[医药卫生—肿瘤]