P物质——甲醛急性刺激效应的分子生物标志物  

Substance P--the biomarker of acute irritation by formaldehyde

作　　者：刘宏亮[1] 童志前[1] 吴江[1] 何胡军[1] 刘军[1] 杨旭[1] 

机构地区：[1]华中师范大学生命科学学院,武汉430079

出　　处：《华中师范大学学报（自然科学版）》2003年第4期540-543,共4页Journal of Central China Normal University：Natural Sciences

基　　金：国家"十五"科技攻关课题(2001BA704B01).

摘　　要：分别用0mg/m3、1mg/m3、2mg/m3、3mg/m3的甲醛对10名受试者进行眼部控制暴露,暴露时间5min,测定暴露前后鼻腔灌洗液中P物质含量.结果表明,甲醛暴露后鼻腔灌洗液中P物质含量增加,尤其是3mg/m3甲醛暴露组P物质含量增加尤为显著(p<0.05).这说明甲醛刺激眼部三叉神经末梢后,会通过局部轴突反射,引起鼻腔内的三叉神经末梢释放P物质.因此P物质可作为评价甲醛急性刺激效应的分子生物标志物.Ten subjects' eyes were exposed to formaldehyde at different doses ((0 mg/m^3,) 1 mg/m^3, 2 mg/m^3, 3 mg/m^3) for five minutes. The content of substance P in the nasal lavage were determined by radio immune assay (RIA). The results showed that the content of substance P increased after exposures, especially during the exposure of 3 mg/m^3 formaldehyde (p<0.05). This maybe explained that formaldehyde could stimulate trigeminal nerve ends of the eyes, which would release substance P from its nasal branches through axon reflex. So we can take the substance P as the molecular biomarker of acute irritation by formaldehyde to investigate the biologic effect of formaldehyde.

关 键 词：甲醛 三叉神经 轴突反射 P物质 鼻腔灌洗液 

分 类 号：X171.5[环境科学与工程—环境科学]